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BZZ1 Bzz1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856514, updated on 9-Dec-2024

Summary

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Official Symbol
BZZ1
Official Full Name
Bzz1p
Primary source
SGD:S000001156
Locus tag
YHR114W
See related
AllianceGenome:SGD:S000001156; FungiDB:YHR114W; VEuPathDB:YHR114W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LSB7
Summary
Enables enzyme activator activity and phospholipid binding activity. Involved in actin nucleation; endocytosis; and response to salt stress. Located in actin cortical patch and plasma membrane. Orthologous to several human genes including FNBP1L (formin binding protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BZZ1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (338083..339984)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene putative cystathionine beta-lyase Neighboring gene aspartyl aminopeptidase Neighboring gene ubiquitin-conjugating protein DMA1 Neighboring gene Cox23p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The WASP/Las17p-interacting protein Bzz1p functions with Myo5p in an early stage of endocytosis. Soulard A, et al. Protoplasma, 2005 Oct. PMID 16231105
  2. Control of lipid organization and actin assembly during clathrin-mediated endocytosis by the cytoplasmic tail of the rhomboid protein Rbd2. Cortesio CL, et al. Mol Biol Cell, 2015 Apr 15. PMID 25694450, Free PMC Article
  3. Membrane-sculpting BAR domains generate stable lipid microdomains. Zhao H, et al. Cell Rep, 2013 Sep 26. PMID 24055060, Free PMC Article
  4. Global genetic determinants of mitochondrial DNA copy number. Zhang H, et al. PLoS One, 2014. PMID 25170845, Free PMC Article
  5. Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. Soulard A, et al. Mol Cell Biol, 2002 Nov. PMID 12391157, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The syndapin-like F-BAR protein Bzz1 functions in a pathway with Rbd2 to control the timing of type 1 myosin recruitment and actin polymerization onset during clathrin-mediated endocytosis.
    Title: Control of lipid organization and actin assembly during clathrin-mediated endocytosis by the cytoplasmic tail of the rhomboid protein Rbd2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament organization IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in actin nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to salt stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to salt stress IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck HDA PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Bzz1p
NP_011982.1
  • SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    338083..339984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179244.1 → NP_011982.1  TPA: Bzz1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011982.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL64, E9P8V2, P38822
    UniProtKB/TrEMBL
    B3LSM9, N1P9F2
    Conserved Domains (3) summary
    cd11777
    Location:497 → 552
    SH3_CIP4_Bzz1_like; Src Homology 3 domain of Cdc42-Interacting Protein 4, Bzz1 and similar domains
    cd11778
    Location:581 → 631
    SH3_Bzz1_2; Second Src Homology 3 domain of Bzz1 and similar domains
    cl12013
    Location:10 → 256
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38822.1

Gene LinkOut

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