U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

COX23 Cox23p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856516, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
COX23
Official Full Name
Cox23p
Primary source
SGD:S000001158
Locus tag
YHR116W
See related
AllianceGenome:SGD:S000001158; FungiDB:YHR116W; VEuPathDB:YHR116W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mitochondrial respiratory chain complex assembly. Located in mitochondrion. Orthologous to human CHCHD7 (coiled-coil-helix-coiled-coil-helix domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See COX23 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (341665..342120)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Bzz1p Neighboring gene ubiquitin-conjugating protein DMA1 Neighboring gene protein channel TOM71 Neighboring gene origin recognition complex subunit 6

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. COX23, a homologue of COX17, is required for cytochrome oxidase assembly. Barros MH, et al. J Biol Chem, 2004 Jul 23. PMID 15145942
  2. The nonsense-mediated mRNA decay (NMD) pathway differentially regulates COX17, COX19 and COX23 mRNAs. Murtha K, et al. Curr Genet, 2019 Apr. PMID 30317392, Free PMC Article
  3. Yeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12. Abe-Kanoh N, et al. Sci Rep, 2019 Jun 20. PMID 31222108, Free PMC Article
  4. Systematic analysis of the twin cx(9)c protein family. Longen S, et al. J Mol Biol, 2009 Oct 23. PMID 19703468
  5. A Role for the Respiratory Chain in Regulating Meiosis Initiation in Saccharomyces cerevisiae. Zhao H, et al. Genetics, 2018 Mar. PMID 29301906, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Cox23p
NP_011984.1
  • Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    341665..342120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179246.1 → NP_011984.1  TPA: Cox23p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011984.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL66, P38824
    UniProtKB/TrEMBL
    A6ZT24, B3LSN1, C7GR62, C8Z9Q9, N1P4N8
    Conserved Domains (1) summary
    pfam06747
    Location:104 → 138
    CHCH; CHCH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38824.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools