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YCK1 serine/threonine protein kinase YCK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856537, updated on 9-Dec-2024

Summary

Official Symbol
YCK1
Official Full Name
serine/threonine protein kinase YCK1
Primary source
SGD:S000001177
Locus tag
YHR135C
See related
AllianceGenome:SGD:S000001177; FungiDB:YHR135C; VEuPathDB:YHR135C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CKI2
Summary
Enables protein serine/threonine kinase activity. Involved in cell morphogenesis; endocytosis; and glucose mediated signaling pathway. Located in plasma membrane. Orthologous to several human genes including CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See YCK1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (372694..374310, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Nsg1p Neighboring gene metalloendopeptidase WSS1 Neighboring gene Spl2p Neighboring gene aromatic-amino-acid:2-oxoglutarate transaminase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by SGD

Items 1 - 25 of 27
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables protein kinase activity PubMed 
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 27
Process Evidence Code Pubs
involved_in cell morphogenesis PubMed 
involved_in chromatin remodeling  
involved_in endocytosis  
involved_in endocytosis PubMed 
involved_in glucose mediated signaling pathway PubMed 
involved_in response to glucose PubMed 
involved_in signal transduction  
Component Evidence Code Pubs
located_in cell periphery PubMed 
is_active_in cytoplasm  
located_in endoplasmic reticulum PubMed 
located_in mitochondrial membrane  
located_in mitochondrion PubMed 
located_in mitochondrion  
is_active_in nucleus  
located_in plasma membrane PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
serine/threonine protein kinase YCK1
NP_012003.1
  • Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK1 has a paralog, YCK2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    372694..374310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179265.1 → NP_012003.1  TPA: serine/threonine protein kinase YCK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012003.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL84, E9P958, P23291
    UniProtKB/TrEMBL
    B3LSP9, C7GTW2, N1P4Q9
    Conserved Domains (1) summary
    cd14127
    Location:68 → 344
    STKc_CK1_fungal; Catalytic domain of the Serine/Threonine protein kinase, Fungal Casein Kinase 1 homolog 1
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