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PEX18 Pex18p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856565, updated on 9-Dec-2024

Summary

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Official Symbol
PEX18
Official Full Name
Pex18p
Primary source
SGD:S000001203
Locus tag
YHR160C
See related
AllianceGenome:SGD:S000001203; FungiDB:YHR160C; VEuPathDB:YHR160C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein import into peroxisome matrix. Located in cytosol and peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PEX18 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (419221..420072, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Kel1p Neighboring gene Tda11p Neighboring gene Yap1801p Neighboring gene mitochondrial pyruvate carrier

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway. Purdue PE, et al. J Cell Biol, 1998 Dec 28. PMID 9864360, Free PMC Article
  2. Pex7p and Pex20p of Neurospora crassa function together in PTS2-dependent protein import into peroxisomes. Sichting M, et al. Mol Biol Cell, 2003 Feb. PMID 12589072, Free PMC Article
  3. Yarrowia lipolytica Pex20p, Saccharomyces cerevisiae Pex18p/Pex21p and mammalian Pex5pL fulfil a common function in the early steps of the peroxisomal PTS2 import pathway. Einwächter H, et al. EMBO Rep, 2001 Nov. PMID 11606420, Free PMC Article
  4. Pex18p is constitutively degraded during peroxisome biogenesis. Purdue PE, et al. J Biol Chem, 2001 Dec 14. PMID 11590152
  5. Cysteine-dependent ubiquitination of Pex18p is linked to cargo translocation across the peroxisomal membrane. Hensel A, et al. J Biol Chem, 2011 Dec 16. PMID 22021076, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. polyubiquitination of Pex18p requires Ubc4p, which cooperates with Pex2p and Pex10p. Monoubiquitination of Pex18p depends on Pex4p (Ubc10p) in concert with Pex12p and Pex10p.
    Title: Distinct ubiquitination cascades act on the peroxisomal targeting signal type 2 co-receptor Pex18p.
  2. The finding indicates that Pex18p export is linked to cargo translocation, which supports the idea of an export-driven import of proteins into peroxisomes.
    Title: Cysteine-dependent ubiquitination of Pex18p is linked to cargo translocation across the peroxisomal membrane.
  3. Data revealed that both PTS-receptors as well as the auxiliary proteins Pex18p and Pex21p are neither required for Pex8p association with the importomer nor for its function as an organizer of the peroxisomal protein import machinery.
    Title: Targeting of Pex8p to the peroxisomal importomer.
  4. Data suggest that the N-terminal half of Pex5p facilitates the import of the major matrix protein Fox1p, and can be functionally replaced by Pex18p.
    Title: Functional similarity between the peroxisomal PTS2 receptor binding protein Pex18p and the N-terminal half of the PTS1 receptor Pex5p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein import into peroxisome matrix IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein import into peroxisome matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pex18p
NP_012030.1
  • Peroxin; required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; primarily responsible for peroxisomal import during growth on oleate, and expression is induced during oleate growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    419221..420072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179291.1 → NP_012030.1  TPA: Pex18p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012030.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLA9, P38855
    UniProtKB/TrEMBL
    B3LSS4, B5VK88, C7GJX8, C8Z9V7, G2WFN4, N1P2X5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38855.1

Gene LinkOut

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