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MPC2 mitochondrial pyruvate carrier [ Saccharomyces cerevisiae S288C ]

Gene ID: 856567, updated on 4-Jan-2025

Summary

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Official Symbol
MPC2
Official Full Name
mitochondrial pyruvate carrier
Primary source
SGD:S000001205
Locus tag
YHR162W
See related
AllianceGenome:SGD:S000001205; FungiDB:YHR162W; VEuPathDB:YHR162W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pyruvate transmembrane transporter activity. Involved in mitochondrial pyruvate transmembrane transport. Located in mitochondrial inner membrane. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See MPC2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (423072..423461)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Pex18p Neighboring gene Yap1801p Neighboring gene 6-phosphogluconolactonase SOL3 Neighboring gene bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes. Wang Z, et al. Biomolecules, 2023 Apr 22. PMID 37238591, Free PMC Article
  2. Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes. Bender T, et al. EMBO J, 2015 Apr 1. PMID 25672363, Free PMC Article
  3. The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state. Tavoulari S, et al. EMBO J, 2019 May 15. PMID 30979775, Free PMC Article
  4. Differential regulation of mitochondrial pyruvate carrier genes modulates respiratory capacity and stress tolerance in yeast. Timón-Gómez A, et al. PLoS One, 2013. PMID 24244496, Free PMC Article
  5. Methionine supplementation stimulates mitochondrial respiration. Tripodi F, et al. Biochim Biophys Acta Mol Cell Res, 2018 Dec. PMID 30290237

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes.
    Title: NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes.
  2. MPC is a hetero-dimer, not a multimeric complex. When not engaged in hetero-dimers, the yeast Mpc proteins can also form homo-dimers that are, however, inactive.
    Title: The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state.
  3. while expression of Mpc1 is not dependent on the carbon source, expression of Mpc2 and Mpc3 is specific to fermentative or respiratory conditions, respectively. This gives rise to two alternative carrier complexes
    Title: Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes.
  4. study concludes that the mitochondrial pyruvate carrier is composed of Mpc1(Ygl080w) and either Mpc2 (Yhr162w) or Mpc3 (Ygr243w); members of the MPC family were found in the inner mitochondrial membrane; mutants lacking MPC proteins showed severe defects in mitochondrial pyruvate uptake
    Title: Identification and functional expression of the mitochondrial pyruvate carrier.
  5. Mpc1 (YGL080W )and Mpc2 (YHR162W) associate to form a complex in the inner mitochondrial membrane; data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier
    Title: A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables pyruvate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyruvate transmembrane transporter activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial pyruvate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial pyruvate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial pyruvate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial pyruvate transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrial pyruvate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial pyruvate carrier
NP_012032.1
  • Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on fermentable carbon sources, and heterodimerizes with Mpc1p to form the fermentative isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC2 paralog, MPC3, heterodimerizes with Mpc1p to form the respiratory MPC isoform

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    423072..423461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179293.1 → NP_012032.1  TPA: mitochondrial pyruvate carrier [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012032.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLB1, P38857
    UniProtKB/TrEMBL
    A6ZT70, B3LSS6, C7GJX7, C8Z9V9, G2WFN6, N1P2E3
    Conserved Domains (1) summary
    pfam03650
    Location:9 → 118
    MPC; Uncharacterized protein family (UPF0041)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38857.1

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