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AIM46 Aim46p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856606, updated on 4-Jan-2025

Summary

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Official Symbol
AIM46
Official Full Name
Aim46p
Primary source
SGD:S000001242
Locus tag
YHR199C
See related
AllianceGenome:SGD:S000001242; FungiDB:YHR199C; VEuPathDB:YHR199C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FMP34
Summary
Enables heme binding activity. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See AIM46 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (497490..498422, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Rix1p Neighboring gene Aim18p Neighboring gene borealin Neighboring gene proteasome regulatory particle base subunit RPN10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae. Schmitz JM, et al. J Biol Chem, 2023 Mar. PMID 36739946, Free PMC Article
  2. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Alkhaja AK, et al. Mol Biol Cell, 2012 Jan. PMID 22114354, Free PMC Article
  3. Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast. Ghosh C, et al. Sci Signal, 2021 May 25. PMID 34035143, Free PMC Article
  4. Synchronized assembly of the oxidative phosphorylation system controls mitochondrial respiration in yeast. Moretti-Horten DN, et al. Dev Cell, 2024 Apr 22. PMID 38508182
  5. Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. Chao JT, et al. Dev Cell, 2019 Oct 21. PMID 31564614, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
    Title: Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables intramolecular lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aim46p
NP_012069.3
  • Hemoprotein; hypothetical protein that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    497490..498422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179330.3 → NP_012069.3  TPA: Aim46p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012069.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZTA5, B3LSV9, B5VKC8, C7GRM1, C8Z9Z9, D3DLE7, P38885
    UniProtKB/TrEMBL
    G2WFS2, N1P315
    Conserved Domains (1) summary
    pfam16035
    Location:97 → 303
    Chalcone_2; Chalcone isomerase like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38885.1

Gene LinkOut

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