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HXT13 hexose transporter HXT13 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856640, updated on 14-Nov-2024

Summary

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Official Symbol
HXT13
Official Full Name
hexose transporter HXT13
Primary source
SGD:S000000795
Locus tag
YEL069C
See related
AllianceGenome:SGD:S000000795; FungiDB:YEL069C; VEuPathDB:YEL069C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HLT1
Summary
Enables D-glucose transmembrane transporter activity; fructose transmembrane transporter activity; and mannose transmembrane transporter activity. Involved in hexose transmembrane transport; mannitol transmembrane transport; and sorbitol transmembrane transport. Located in endoplasmic reticulum. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HXT13 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (21537..23231, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene D-lactate dehydrogenase Neighboring gene mannitol dehydrogenase DSF1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene D-amino-acid N-acetyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional characterization of the hexose transporter Hxt13p: an efflux pump that mediates resistance to miltefosine in yeast. Biswas C, et al. Fungal Genet Biol, 2013 Dec. PMID 24076076
  2. Genomic and transcriptomic analyses of the Chinese Maotai-flavored liquor yeast MT1 revealed its unique multi-carbon co-utilization. Lu X, et al. BMC Genomics, 2015 Dec 15. PMID 26666414, Free PMC Article
  3. Expression of the HXT13, HXT15 and HXT17 genes in Saccharomyces cerevisiae and stabilization of the HXT1 gene transcript by sugar-induced osmotic stress. Greatrix BW, et al. Curr Genet, 2006 Apr. PMID 16397765
  4. Transcription of hexose transporters of Saccharomyces cerevisiae is affected by change in oxygen provision. Rintala E, et al. BMC Microbiol, 2008 Mar 28. PMID 18373847, Free PMC Article
  5. Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters. Jordan P, et al. Sci Rep, 2016 Mar 21. PMID 26996892, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Show that Hxt13, Hxt15, Hxt16 and Hxt17 transport two major hexitols in nature, mannitol and sorbitol, with moderate affinities, by a facilitative mechanism.
    Title: Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters.
  2. Authors identified a new function of the hexose sugar transporter gene HXT13 when overexpressed in Saccharomyces cerevisiae, namely, in efflux of miltefosine and in mediating miltefosine resistance.
    Title: Functional characterization of the hexose transporter Hxt13p: an efflux pump that mediates resistance to miltefosine in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mannose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannitol transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mannose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sorbitol transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hexose transporter HXT13
NP_010845.1
  • Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    21537..23231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178884.1 → NP_010845.1  TPA: hexose transporter HXT13 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010845.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLI2, P39924
    UniProtKB/TrEMBL
    A6ZQN4
    Conserved Domains (1) summary
    pfam00083
    Location:60 → 521
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39924.1

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