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POL5 DNA-directed DNA polymerase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856655, updated on 9-Dec-2024

Summary

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Official Symbol
POL5
Official Full Name
DNA-directed DNA polymerase
Primary source
SGD:S000000781
Locus tag
YEL055C
See related
AllianceGenome:SGD:S000000781; FungiDB:YEL055C; VEuPathDB:YEL055C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables rDNA binding activity and rRNA primary transcript binding activity. Involved in positive regulation of ribosome biogenesis; rRNA metabolic process; and ribosomal large subunit assembly. Located in nucleolus. Orthologous to human MYBBP1A (MYB binding protein 1a). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See POL5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (48471..51539, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Sdd1p Neighboring gene Hat2p Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L12A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast POL5 is an evolutionarily conserved regulator of rDNA transcription unrelated to any known DNA polymerases. Yang W, et al. Cell Cycle, 2003 Mar-Apr. PMID 12695662
  2. The fifth essential DNA polymerase phi in Saccharomyces cerevisiae is localized to the nucleolus and plays an important role in synthesis of rRNA. Shimizu K, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12093911, Free PMC Article
  3. Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae. Ramos-Sáenz A, et al. RNA, 2019 Nov. PMID 31413149, Free PMC Article
  4. Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit. Braun CM, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31745560, Free PMC Article
  5. Proteins and RNA sequences required for the transition of the t-Utp complex into the SSU processome. Gallagher JEG. FEMS Yeast Res, 2019 Jan 1. PMID 30445532, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit.
    Title: Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables rDNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rDNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA primary transcript binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ribosome biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed DNA polymerase
NP_010859.1
  • Protein involved in 60S assembly and pre-40S AFs recycling; has sequence similarity to human MybBP1A and weak sequence similarity to B-type DNA polymerases; not required for chromosomal DNA replication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    48471..51539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178870.1 → NP_010859.1  TPA: DNA-directed DNA polymerase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010859.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLJ5, P39985, Q9Y737
    UniProtKB/TrEMBL
    C7GXE2, N1P5B5
    Conserved Domains (1) summary
    pfam04931
    Location:46 → 859
    DNA_pol_phi; DNA polymerase phi
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39985.1

Gene LinkOut

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