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MADD MAP kinase activating death domain [ Homo sapiens (human) ]

Gene ID: 8567, updated on 27-Nov-2024

Summary

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Official Symbol
MADDprovided by HGNC
Official Full Name
MAP kinase activating death domainprovided by HGNC
Primary source
HGNC:HGNC:6766
See related
Ensembl:ENSG00000110514 MIM:603584; AllianceGenome:HGNC:6766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DENN; IG20; DEEAH; RabGEF; NEDDISH; RAB3GEP
Summary
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 27.7), testis (RPKM 18.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See MADD in Genome Data Viewer
Location:
11p11.2
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (47269188..47330031)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (47425958..47486853)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47290739..47351582)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:47236089-47237288 Neighboring gene damage specific DNA binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4694 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:47270641-47270808 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:47280987-47281555 Neighboring gene nuclear receptor subfamily 1 group H member 3 Neighboring gene Sharpr-MPRA regulatory region 2100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4695 Neighboring gene Sharpr-MPRA regulatory region 9889 Neighboring gene MADD antisense RNA 1 Neighboring gene myosin binding protein C3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47371915-47372896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47372897-47373877 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:47387327-47387502 Neighboring gene Spi-1 proto-oncogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47395717-47396218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4697 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47399745-47400696

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Expression of MADD in lung adenocarcinoma tissues and its effects on proliferation and apoptosis of lung adenocarcinoma A549 cells]. Wei YP, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012 Apr. PMID 22482404
  2. Homozygous variant in MADD, encoding a Rab guanine nucleotide exchange factor, results in pleiotropic effects and a multisystemic disorder. Abu-Libdeh B, et al. Eur J Hum Genet, 2021 Jun. PMID 33723354, Free PMC Article
  3. Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder. Schneeberger PE, et al. Brain, 2020 Aug 1. PMID 32761064, Free PMC Article
  4. MADD Expression in Lung Adenocarcinoma and its Impact on Proliferation and Apoptosis of Lung Adenocarcinoma Cells. Ye B, et al. Comb Chem High Throughput Screen, 2019. PMID 30947659
  5. Loss of MADD expression inhibits cellular growth and metastasis in anaplastic thyroid cancer. Saini S, et al. Cell Death Dis, 2019 Feb 13. PMID 30760700, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New insights into the clinical and molecular spectrum of the MADD-related neurodevelopmental disorder.
    Title: New insights into the clinical and molecular spectrum of the MADD-related neurodevelopmental disorder.
  2. MADD regulates natural killer cell degranulation through Rab27a activation.
    Title: MADD regulates natural killer cell degranulation through Rab27a activation.
  3. Calloso-adreno-scrotal agenesis associated with biallelic MAPK-activating death domain protein (MADD) variant: Further phenotypic delineation of MADD deficiency.
    Title: Calloso-adreno-scrotal agenesis associated with biallelic MAPK-activating death domain protein (MADD) variant: Further phenotypic delineation of MADD deficiency.
  4. Homozygous variant in MADD, encoding a Rab guanine nucleotide exchange factor, results in pleiotropic effects and a multisystemic disorder.
    Title: Homozygous variant in MADD, encoding a Rab guanine nucleotide exchange factor, results in pleiotropic effects and a multisystemic disorder.
  5. GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies.
    Title: GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies.
  6. Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.
    Title: Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.
  7. Authors show the crucial role of MADD in ATC tumorigenesis and metastasis.
    Title: Loss of MADD expression inhibits cellular growth and metastasis in anaplastic thyroid cancer.
  8. MADD Expression in Lung Adenocarcinoma and its Impact on Proliferation and Apoptosis of Lung Adenocarcinoma Cells
    Title: MADD Expression in Lung Adenocarcinoma and its Impact on Proliferation and Apoptosis of Lung Adenocarcinoma Cells.
  9. The risk of coronary disease and ischemic stroke associated with multiple polymorphisms and haplotypes of MADD and FOLH1 in Han Chinese patients are reported in association with alcohol consumption.
    Title: MADD-FOLH1 Polymorphisms and Their Haplotypes with Serum Lipid Levels and the Risk of Coronary Heart Disease and Ischemic Stroke in a Chinese Han Population.
  10. miR-3151 silencing by DNA methylation protected chronic lymphocytic leukemia cells from apoptosis by over-expression of its direct targets MADD and PIK3R2, constitutive activation of MEK/ERK and PI3K/AKT signaling , and over-expression of MCL1.
    Title: Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Deeah syndrome
MedGen: C5436579 OMIM: 619004 GeneReviews: Not available
Compare labs
Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia
MedGen: C5436585 OMIM: 619005 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
EBI GWAS Catalog
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
EBI GWAS Catalog
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
EBI GWAS Catalog
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35600, FLJ36300, KIAA0358

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables death receptor binding TAS
Traceable Author Statement
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rab protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
MAP kinase-activating death domain protein
Names
Insuloma-Glucagonoma protein 20
Rab3 GDP/GTP exchange factor
differentially expressed in normal and neoplastic cells
insulinoma glucagonoma clone 20
rab3 GDP/GTP exchange protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029462.2 RefSeqGene

    Range
    5947..65845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135943.2 → NP_001129415.1  MAP kinase-activating death domain protein isoform 9

    See identical proteins and their annotated locations for NP_001129415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, and uses two alternate in-frame splice sites and lacks three alternate in-frame exons in the mid coding region, compared to variant 4. The resulting isoform (i) is shorter than isoform d.
    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  2. NM_001135944.2 → NP_001129416.1  MAP kinase-activating death domain protein isoform 10

    See identical proteins and their annotated locations for NP_001129416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses two alternate in-frame splice sites and lacks three alternate in-frame exons in the mid coding region, compared to variant 4. The resulting isoform (j) is shorter than isoform d.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44589.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Related
    ENSP00000378753.3, ENST00000395344.7
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  3. NM_001376571.1 → NP_001363500.1  MAP kinase-activating death domain protein isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PXF1, A0A9L9PYF5
    Related
    ENSP00000516604.1, ENST00000706887.1
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  4. NM_001376572.1 → NP_001363501.1  MAP kinase-activating death domain protein isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  5. NM_001376573.1 → NP_001363502.1  MAP kinase-activating death domain protein isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  6. NM_001376574.1 → NP_001363503.1  MAP kinase-activating death domain protein isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  7. NM_001376575.1 → NP_001363504.1  MAP kinase-activating death domain protein isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  8. NM_001376576.1 → NP_001363505.1  MAP kinase-activating death domain protein isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A0U1RR25, A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  9. NM_001376577.1 → NP_001363506.1  MAP kinase-activating death domain protein isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A0U1RR25, A0A9L9PYF5
    Related
    ENSP00000489300.2, ENST00000634938.2
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  10. NM_001376578.1 → NP_001363507.1  MAP kinase-activating death domain protein isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (4) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03132
    Location:717 → 908
    PHA03132; thymidine kinase; Provisional

  11. NM_001376579.1 → NP_001363508.1  MAP kinase-activating death domain protein isoform 77

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  12. NM_001376580.1 → NP_001363509.1  MAP kinase-activating death domain protein isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  13. NM_001376581.1 → NP_001363510.1  MAP kinase-activating death domain protein isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PXZ0, A0A9L9PYF5
    Related
    ENSP00000516602.1, ENST00000706886.1
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  14. NM_001376582.1 → NP_001363511.1  MAP kinase-activating death domain protein isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  15. NM_001376583.1 → NP_001363512.1  MAP kinase-activating death domain protein isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  16. NM_001376584.1 → NP_001363513.1  MAP kinase-activating death domain protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS7931.1
    UniProtKB/TrEMBL
    A0A0A0MRB5, A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  17. NM_001376585.1 → NP_001363514.1  MAP kinase-activating death domain protein isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  18. NM_001376586.1 → NP_001363515.1  MAP kinase-activating death domain protein isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  19. NM_001376593.1 → NP_001363522.1  MAP kinase-activating death domain protein isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  20. NM_001376594.1 → NP_001363523.1  MAP kinase-activating death domain protein isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  21. NM_001376595.1 → NP_001363524.1  MAP kinase-activating death domain protein isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PXN0, A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  22. NM_001376596.1 → NP_001363525.1  MAP kinase-activating death domain protein isoform 76

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  23. NM_001376597.1 → NP_001363526.1  MAP kinase-activating death domain protein isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PXN0, A0A9L9PYF5
    Related
    ENSP00000516606.1, ENST00000706889.1
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  24. NM_001376598.1 → NP_001363527.1  MAP kinase-activating death domain protein isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  25. NM_001376599.1 → NP_001363528.1  MAP kinase-activating death domain protein isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PXZ3, A0A9L9PYF5
    Related
    ENSP00000516607.1, ENST00000706890.1
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  26. NM_001376600.1 → NP_001363529.1  MAP kinase-activating death domain protein isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PXZ3, A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  27. NM_001376601.1 → NP_001363530.1  MAP kinase-activating death domain protein isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PXZ3, A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  28. NM_001376602.1 → NP_001363531.1  MAP kinase-activating death domain protein isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  29. NM_001376603.1 → NP_001363532.1  MAP kinase-activating death domain protein isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  30. NM_001376604.1 → NP_001363533.1  MAP kinase-activating death domain protein isoform 75

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  31. NM_001376605.1 → NP_001363534.1  MAP kinase-activating death domain protein isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Related
    ENSP00000516605.1, ENST00000706888.1
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  32. NM_001376606.1 → NP_001363535.1  MAP kinase-activating death domain protein isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  33. NM_001376607.1 → NP_001363536.1  MAP kinase-activating death domain protein isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  34. NM_001376608.1 → NP_001363537.1  MAP kinase-activating death domain protein isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  35. NM_001376609.1 → NP_001363538.1  MAP kinase-activating death domain protein isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  36. NM_001376610.1 → NP_001363539.1  MAP kinase-activating death domain protein isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  37. NM_001376611.1 → NP_001363540.1  MAP kinase-activating death domain protein isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  38. NM_001376612.1 → NP_001363541.1  MAP kinase-activating death domain protein isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  39. NM_001376613.1 → NP_001363542.1  MAP kinase-activating death domain protein isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  40. NM_001376614.1 → NP_001363543.1  MAP kinase-activating death domain protein isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  41. NM_001376615.1 → NP_001363544.1  MAP kinase-activating death domain protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44588.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  42. NM_001376616.1 → NP_001363545.1  MAP kinase-activating death domain protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44588.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  43. NM_001376617.1 → NP_001363546.1  MAP kinase-activating death domain protein isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  44. NM_001376618.1 → NP_001363547.1  MAP kinase-activating death domain protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44589.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  45. NM_001376619.1 → NP_001363548.1  MAP kinase-activating death domain protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44589.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  46. NM_001376620.1 → NP_001363549.1  MAP kinase-activating death domain protein isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  47. NM_001376621.1 → NP_001363550.1  MAP kinase-activating death domain protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44589.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  48. NM_001376622.1 → NP_001363551.1  MAP kinase-activating death domain protein isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  49. NM_001376623.1 → NP_001363552.1  MAP kinase-activating death domain protein isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  50. NM_001376624.1 → NP_001363553.1  MAP kinase-activating death domain protein isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  51. NM_001376625.1 → NP_001363554.1  MAP kinase-activating death domain protein isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  52. NM_001376626.1 → NP_001363555.1  MAP kinase-activating death domain protein isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PY22, A0A9L9PYF5
    Related
    ENSP00000516608.1, ENST00000706891.1
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  53. NM_001376627.1 → NP_001363556.1  MAP kinase-activating death domain protein isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  54. NM_001376628.1 → NP_001363557.1  MAP kinase-activating death domain protein isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  55. NM_001376629.1 → NP_001363558.1  MAP kinase-activating death domain protein isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  56. NM_001376630.1 → NP_001363559.1  MAP kinase-activating death domain protein isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  57. NM_001376631.1 → NP_001363560.1  MAP kinase-activating death domain protein isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (4) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03132
    Location:717 → 908
    PHA03132; thymidine kinase; Provisional

  58. NM_001376632.1 → NP_001363561.1  MAP kinase-activating death domain protein isoform 48

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  59. NM_001376633.1 → NP_001363562.1  MAP kinase-activating death domain protein isoform 49

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  60. NM_001376634.1 → NP_001363563.1  MAP kinase-activating death domain protein isoform 50

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  61. NM_001376635.1 → NP_001363564.1  MAP kinase-activating death domain protein isoform 51

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  62. NM_001376636.1 → NP_001363565.1  MAP kinase-activating death domain protein isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  63. NM_001376637.1 → NP_001363566.1  MAP kinase-activating death domain protein isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  64. NM_001376638.1 → NP_001363567.1  MAP kinase-activating death domain protein isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  65. NM_001376639.1 → NP_001363568.1  MAP kinase-activating death domain protein isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  66. NM_001376640.1 → NP_001363569.1  MAP kinase-activating death domain protein isoform 54

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  67. NM_001376641.1 → NP_001363570.1  MAP kinase-activating death domain protein isoform 55

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  68. NM_001376642.1 → NP_001363571.1  MAP kinase-activating death domain protein isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  69. NM_001376643.1 → NP_001363572.1  MAP kinase-activating death domain protein isoform 56

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  70. NM_001376644.1 → NP_001363573.1  MAP kinase-activating death domain protein isoform 57

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  71. NM_001376645.1 → NP_001363574.1  MAP kinase-activating death domain protein isoform 58

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  72. NM_001376646.1 → NP_001363575.1  MAP kinase-activating death domain protein isoform 59

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  73. NM_001376647.1 → NP_001363576.1  MAP kinase-activating death domain protein isoform 60

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PY18, A0A9L9PYF5
    Related
    ENSP00000516603.1, ENST00000526603.6
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  74. NM_001376648.1 → NP_001363577.1  MAP kinase-activating death domain protein isoform 61

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  75. NM_001376649.1 → NP_001363578.1  MAP kinase-activating death domain protein isoform 62

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  76. NM_001376650.1 → NP_001363579.1  MAP kinase-activating death domain protein isoform 63

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  77. NM_001376651.1 → NP_001363580.1  MAP kinase-activating death domain protein isoform 64

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  78. NM_001376652.1 → NP_001363581.1  MAP kinase-activating death domain protein isoform 64

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  79. NM_001376653.1 → NP_001363582.1  MAP kinase-activating death domain protein isoform 65

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  80. NM_001376654.1 → NP_001363583.1  MAP kinase-activating death domain protein isoform 66

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  81. NM_001376655.1 → NP_001363584.1  MAP kinase-activating death domain protein isoform 67

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  82. NM_001376656.1 → NP_001363585.1  MAP kinase-activating death domain protein isoform 78

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  83. NM_001376657.1 → NP_001363586.1  MAP kinase-activating death domain protein isoform 68

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  84. NM_001376658.1 → NP_001363587.1  MAP kinase-activating death domain protein isoform 69

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  85. NM_001376659.1 → NP_001363588.1  MAP kinase-activating death domain protein isoform 70

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  86. NM_001376660.1 → NP_001363589.1  MAP kinase-activating death domain protein isoform 71

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:418 → 486
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:105 → 334
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    cl04085
    Location:4 → 30
    uDENN; uDENN domain

  87. NM_001376661.1 → NP_001363590.1  MAP kinase-activating death domain protein isoform 72

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  88. NM_001376662.1 → NP_001363591.1  MAP kinase-activating death domain protein isoform 73

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  89. NM_001376663.1 → NP_001363592.1  MAP kinase-activating death domain protein isoform 74

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Conserved Domains (2) summary
    smart00801
    Location:264 → 332
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:28 → 180
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

  90. NM_003682.4 → NP_003673.3  MAP kinase-activating death domain protein isoform 4

    See identical proteins and their annotated locations for NP_003673.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS7930.1
    UniProtKB/Swiss-Prot
    A8K8S7, B5MEE5, D3DQR4, O15065, O15293, Q15732, Q15741, Q8IWD7, Q8WXG3, Q8WXG4, Q8WXG5, Q8WXG6, Q8WZ63
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Related
    ENSP00000310933.4, ENST00000311027.9
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  91. NM_130470.3 → NP_569826.2  MAP kinase-activating death domain protein isoform 1

    See identical proteins and their annotated locations for NP_569826.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has a different exon 1 sequence and lacks exons 16, 21 and 26, as compared to transcript variant 4. The resulting isoform (a) is shorter than isoform d.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS7931.1
    UniProtKB/TrEMBL
    A0A0A0MRB5, A0A9L9PYF5
    Related
    ENSP00000343902.4, ENST00000342922.8
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  92. NM_130471.3 → NP_569827.2  MAP kinase-activating death domain protein isoform 2

    See identical proteins and their annotated locations for NP_569827.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exons 21, 26, and a portion of exon 13 as compared to transcript variant 4. The resulting isoform (b) is missing regions of 43 aa, 18 aa, and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44587.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Related
    ENSP00000384204.3, ENST00000407859.7
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  93. NM_130472.3 → NP_569828.2  MAP kinase-activating death domain protein isoform 3

    See identical proteins and their annotated locations for NP_569828.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks exons 16, 21, 26, and a portion of exon 13 as compared to transcript variant 4. The resulting isoform (c) is missing regions of 43 aa, 20 aa, 18 aa, and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44588.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Related
    ENSP00000385585.1, ENST00000402799.5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  94. NM_130473.3 → NP_569829.2  MAP kinase-activating death domain protein isoform 5

    See identical proteins and their annotated locations for NP_569829.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks exons 21 and 26 as compared to transcript variant 4. The resulting isoform (e) is missing regions of 18 aa and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS7932.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Related
    ENSP00000304505.6, ENST00000349238.7
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  95. NM_130474.3 → NP_569830.2  MAP kinase-activating death domain protein isoform 6

    See identical proteins and their annotated locations for NP_569830.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks exons 16, 21, 26, 34, and part of exon 13 but maintains the same reading frame up through exon 33 as compared to transcript variant 4. The resulting isoform (f) is missing regions of 43 aa, 20 aa, 18 aa, and 21 aa and has a different carboxyl terminus as compared to isoform d.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44590.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Related
    ENSP00000384435.1, ENST00000406482.5
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  96. NM_130475.3 → NP_569831.1  MAP kinase-activating death domain protein isoform 7

    See identical proteins and their annotated locations for NP_569831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has a different exon 1 sequence and lacks exon 34 as compared to transcript variant 4. The resulting isoform (g) is shorter and has a different carboxyl terminus as compared to the isoform (d) encoded by transcript variant 4.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS41642.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Related
    ENSP00000378745.3, ENST00000395336.7
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  97. NM_130476.3 → NP_569832.2  MAP kinase-activating death domain protein isoform 8

    See identical proteins and their annotated locations for NP_569832.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has a different exon 1 sequence, lacks exons 16, 21 and 26, and uses an alternate in-frame splice site in exon 23, as compared to transcript variant 4. The resulting isoform (h) is shorter than isoform d.
    Source sequence(s)
    AC018410, AC090582
    Consensus CDS
    CCDS44586.1
    UniProtKB/TrEMBL
    A0A9L9PYF5
    Related
    ENSP00000384287.2, ENST00000402192.6
    Conserved Domains (3) summary
    smart00801
    Location:486 → 554
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:173 → 402
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:8 → 98
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RNA

  1. NR_164835.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582

  2. NR_164836.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582

  3. NR_164837.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582

  4. NR_164838.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582

  5. NR_164839.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582

  6. NR_164840.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582

  7. NR_164841.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582

  8. NR_164842.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018410, AC090582

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    47269188..47330031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    47425958..47486853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXG6.2 GenPept UniProtKB/Swiss-Prot:Q8WXG6

Gene LinkOut

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