U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

VAB2 Vab2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856713, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
VAB2
Official Full Name
Vab2p
Primary source
SGD:S000000731
Locus tag
YEL005C
See related
AllianceGenome:SGD:S000000731; FungiDB:YEL005C; VEuPathDB:YEL005C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
VAB31
Summary
Involved in endosome organization and regulation of protein localization. Located in cytoplasm. Part of BLOC-1 complex. [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See VAB2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (145907..146755, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Mit1p Neighboring gene NAD+ transporter Neighboring gene Yea4p Neighboring gene tubulin-binding prefolding complex subunit GIM4

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. Pan X, et al. Mol Biol Cell, 2000 Jul. PMID 10888680, Free PMC Article
  2. Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1. Hayes MJ, et al. Traffic, 2011 Mar. PMID 21159114, Free PMC Article
  3. Vac8p, an armadillo repeat protein, coordinates vacuole inheritance with multiple vacuolar processes. Tang F, et al. Traffic, 2006 Oct. PMID 16824055
  4. The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3. John Peter AT, et al. J Cell Biol, 2013 Apr 1. PMID 23547030, Free PMC Article
  5. Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole. Rana M, et al. Mol Biol Cell, 2015 Jul 1. PMID 25971802, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of BLOC-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Vab2p
NP_010911.3
  • Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Vps21p-GFP; has potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of; Vab2p-GFP-fusion localizes to cytoplasm in punctate pattern

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    145907..146755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178820.3 → NP_010911.3  TPA: Vab2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010911.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZQU2, D3DLP2, P40003
    UniProtKB/TrEMBL
    C7GKH4, C8Z6Z4, G2WCM6, N1P7F7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40003.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools