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NTF2 Ran GTPase-binding protein NTF2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856727, updated on 9-Dec-2024

Summary

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Official Symbol
NTF2
Official Full Name
Ran GTPase-binding protein NTF2
Primary source
SGD:S000000811
Locus tag
YER009W
See related
AllianceGenome:SGD:S000000811; FungiDB:YER009W; VEuPathDB:YER009W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables small GTPase binding activity. Involved in protein import into nucleus. Located in nuclear envelope. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NTF2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (172115..172492)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GTP-Rho binding exocyst subunit SEC3 Neighboring gene bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase Neighboring gene GPI-anchored mannoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Probing a structural model of the nuclear pore complex channel through molecular dynamics. Miao L, et al. Biophys J, 2010 Apr 21. PMID 20409487, Free PMC Article
  2. The NTF2 gene encodes an essential, highly conserved protein that functions in nuclear transport in vivo. Corbett AH, et al. J Biol Chem, 1996 Aug 2. PMID 8702493
  3. Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats. Bayliss R, et al. EMBO J, 2002 Jun 17. PMID 12065398, Free PMC Article
  4. Tuning Selective Transport of Biomolecules through Site-Mutated Nucleoporin-like Protein (NLP) Hydrogels. Yang YJ, et al. Biomacromolecules, 2021 Feb 8. PMID 33428378
  5. Functional analysis of the hydrophobic patch on nuclear transport factor 2 involved in interactions with the nuclear pore in vivo. Quimby BB, et al. J Biol Chem, 2001 Oct 19. PMID 11489893

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ran GTPase-binding protein NTF2
NP_010925.1
  • Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    172115..172492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178900.1 → NP_010925.1  TPA: Ran GTPase-binding protein NTF2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010925.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLQ6, P33331
    UniProtKB/TrEMBL
    A6ZQV6, B3LS21, C7GKI7, C8Z709, G2WCP0, N1P5G2
    Conserved Domains (1) summary
    cd00780
    Location:4 → 123
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33331.2

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