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PRO3 pyrroline-5-carboxylate reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856744, updated on 4-Jan-2025

Summary

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Official Symbol
PRO3
Official Full Name
pyrroline-5-carboxylate reductase
Primary source
SGD:S000000825
Locus tag
YER023W
See related
AllianceGenome:SGD:S000000825; FungiDB:YER023W; VEuPathDB:YER023W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ORE2
Summary
Enables pyrroline-5-carboxylate reductase activity. Involved in proline biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB; autosomal recessive cutis laxa type IIIB; and hypomyelinating leukodystrophy 10. Orthologous to human PYCR1 (pyrroline-5-carboxylate reductase 1); PYCR2 (pyrroline-5-carboxylate reductase 2); and PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PRO3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (201076..201936)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle lid subunit RPN3 Neighboring gene Srb4p Neighboring gene carnitine O-acetyltransferase YAT2 Neighboring gene translation initiation factor eIF2 subunit gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and sequence analysis of the cDNA encoding delta 1-pyrroline-5-carboxylate reductase from Zalerion arboricola. Kelly R, et al. Gene, 1996 Jun 12. PMID 8654976
  2. Proline biosynthesis in Saccharomyces cerevisiae: analysis of the PRO3 gene, which encodes delta 1-pyrroline-5-carboxylate reductase. Brandriss MC, et al. J Bacteriol, 1992 Jun. PMID 1592829, Free PMC Article
  3. Subcellular compartmentation in control of converging pathways for proline and arginine metabolism in Saccharomyces cerevisiae. Brandriss MC, et al. J Bacteriol, 1981 Mar. PMID 7009582, Free PMC Article
  4. ore2, a mutation affecting proline biosynthesis in the yeast Saccharomyces cerevisiae, leads to a cdc phenotype. Neuville P, et al. Mol Gen Genet, 1992 Aug. PMID 1508147
  5. The Cdc25/Ras/cAMP-dependent protein kinase A signaling pathway regulates proline utilization in wine yeast Saccharomyces cerevisiae under a wine fermentation model. Nishimura A, et al. Biosci Biotechnol Biochem, 2022 Aug 24. PMID 35749464

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrroline-5-carboxylate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrroline-5-carboxylate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrroline-5-carboxylate reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proline biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pyrroline-5-carboxylate reductase
NP_010940.3
  • Cytosolic delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    201076..201936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178914.3 → NP_010940.3  TPA: pyrroline-5-carboxylate reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010940.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLS2, P32263
    UniProtKB/TrEMBL
    A6ZQX2, B3LS36, C7GTD5, C8Z724, G2WCQ6, N1P5I0
    Conserved Domains (1) summary
    COG0345
    Location:2 → 284
    ProC; Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32263.1

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