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PTP3 tyrosine protein phosphatase PTP3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856807, updated on 4-Jan-2025

Summary

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Official Symbol
PTP3
Official Full Name
tyrosine protein phosphatase PTP3
Primary source
SGD:S000000877
Locus tag
YER075C
See related
AllianceGenome:SGD:S000000877; FungiDB:YER075C; VEuPathDB:YER075C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein tyrosine phosphatase activity. Involved in several processes, including cytoplasmic sequestering of protein; negative regulation of cell integrity MAPK cascade; and pheromone response MAPK cascade. Located in nucleus. Is active in cytoplasm. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PTP3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (308413..311199, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S24A Neighboring gene Yos1p Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation. Zhan XL, et al. Mol Biol Cell, 2000 Feb. PMID 10679022, Free PMC Article
  2. A rate threshold mechanism regulates MAPK stress signaling and survival. Johnson AN, et al. Proc Natl Acad Sci U S A, 2021 Jan 12. PMID 33443180, Free PMC Article
  3. Two protein-tyrosine phosphatases inactivate the osmotic stress response pathway in yeast by targeting the mitogen-activated protein kinase, Hog1. Jacoby T, et al. J Biol Chem, 1997 Jul 11. PMID 9211927
  4. A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase. Zhan XL, et al. Genes Dev, 1999 Nov 1. PMID 10557209, Free PMC Article
  5. Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Mattison CP, et al. Genes Dev, 2000 May 15. PMID 10817757, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A rate threshold mechanism regulates MAPK stress signaling and survival.
    Title: A rate threshold mechanism regulates MAPK stress signaling and survival.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular hyperosmotic response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic sequestering of protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization or biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cell integrity MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pheromone response MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of sporulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tyrosine protein phosphatase PTP3
NP_010998.2
  • Phosphotyrosine-specific protein phosphatase; major role in the pheromone adaptive response through dephosphorylation of the Fus3p MAPK with a minor role by Ptp2p and Msg5p; minor role in the inactivation of Hog1p MAPK during osmolarity sensing with major role by Ptp2p; dephosphorylates and regulates the localization of Hog1p; minor role in the cell wall integrity pathway through tyrosine dephosphorylation of the MAPK Slt2p while Ptp2p plays a major role; localizes to the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    308413..311199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178966.2 → NP_010998.2  TPA: tyrosine protein phosphatase PTP3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010998.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLY1, P40048
    UniProtKB/TrEMBL
    B3LRJ2, C7GRQ7, C8Z784
    Conserved Domains (2) summary
    cd01446
    Location:97 → 231
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd18533
    Location:571 → 873
    PTP_fungal; fungal protein tyrosine phosphatases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40048.2

Gene LinkOut

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