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PTC2 type 2C protein phosphatase PTC2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856823, updated on 4-Jan-2025

Summary

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Official Symbol
PTC2
Official Full Name
type 2C protein phosphatase PTC2
Primary source
SGD:S000000891
Locus tag
YER089C
See related
AllianceGenome:SGD:S000000891; FungiDB:YER089C; VEuPathDB:YER089C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables MAP kinase serine/threonine phosphatase activity. Involved in negative regulation of endoplasmic reticulum unfolded protein response. Located in cytoplasm and nucleus. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A); PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E); and PPM1N (protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See PTC2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (335946..337340, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Arf family guanine nucleotide exchange factor SBH1 Neighboring gene Dot6p Neighboring gene anthranilate synthase TRP2 Neighboring gene 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ire1 and ptc2 genes involved in the unfolded protein response pathway in the filamentous fungus Trichoderma reesei. Valkonen M, et al. Mol Genet Genomics, 2004 Nov. PMID 15480788
  2. Bypass of Activation Loop Phosphorylation by Aspartate 836 in Activation of the Endoribonuclease Activity of Ire1. Armstrong MC, et al. Mol Cell Biol, 2017 Aug 15. PMID 28559428, Free PMC Article
  3. Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae. Szyjka SJ, et al. Genes Dev, 2008 Jul 15. PMID 18628397, Free PMC Article
  4. Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Welihinda AA, et al. Mol Cell Biol, 1998 Apr. PMID 9528768, Free PMC Article
  5. Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination. Kim JA, et al. Mol Cell Biol, 2011 Feb. PMID 21135129, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS140 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum unfolded protein response IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
type 2C protein phosphatase PTC2
NP_011013.1
  • Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    335946..337340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178980.1 → NP_011013.1  TPA: type 2C protein phosphatase PTC2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011013.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLZ6, P39966
    UniProtKB/TrEMBL
    A6ZR45, B3LRK7, C7GRS2, C8Z7A5, G2WCY0, N1P4Z2
    Conserved Domains (1) summary
    pfam00481
    Location:23 → 279
    PP2C; Protein phosphatase 2C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39966.1

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