MET6 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MET6
Official Full Name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
Primary source: SGD:S000000893
Locus tag: YER091C
See related: AllianceGenome:SGD:S000000893; FungiDB:YER091C; VEuPathDB:YER091C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity. Involved in methionine biosynthetic process. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MET6 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (339864..342167, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data showed that co-expression of MET6 and SAM2 improved intracellular methionine availability and redirected the methionine to S-adenosyl-L-methionine biosynthesis.
Title: Improving methionine and ATP availability by MET6 and SAM2 co-expression combined with sodium citrate feeding enhanced SAM accumulation in Saccharomyces cerevisiae.
We conclude that ScMET 6p and CaMET 6p require a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to the bacterial metE homologs.
Title: Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables S-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methionine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

NP_011015.3

EC 2.1.1.14

Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

339864..342167 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178982.3 → NP_011015.3 TPA: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011015.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLZ8, P05694, P38010, Q02488, Q27JJ8

UniProtKB/TrEMBL

A6ZR47, B3LRK9, C7GRS4, C8Z7A8, E9P9C8, G2WCY2, N1PA49

Conserved Domains (1) summary

TIGR01371
Location:7 → 764

met_syn_B12ind; 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase