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AST2 Ast2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856838, updated on 9-Dec-2024

Summary

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Official Symbol
AST2
Official Full Name
Ast2p
Primary source
SGD:S000000903
Locus tag
YER101C
See related
AllianceGenome:SGD:S000000903; FungiDB:YER101C; VEuPathDB:YER101C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable oxidoreductase activity. Involved in protein targeting to membrane. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See AST2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (360502..361794, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribose phosphate diphosphokinase subunit PRS2 Neighboring gene E2 ubiquitin-conjugating protein UBC6 Neighboring gene ribosomal 40S subunit protein S8B Neighboring gene Hsp70 family chaperone SSA4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel AST2 mutation generated upon whole-genome transformation of Saccharomyces cerevisiae confers high tolerance to 5-Hydroxymethylfurfural (HMF) and other inhibitors. Vanmarcke G, et al. PLoS Genet, 2021 Oct. PMID 34624020, Free PMC Article
  2. Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole. Chang A, et al. J Cell Biol, 1995 Jan. PMID 7822420, Free PMC Article
  3. Diversity, taxonomy and evolution of medium-chain dehydrogenase/reductase superfamily. Riveros-Rosas H, et al. Eur J Biochem, 2003 Aug. PMID 12899689
  4. The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicators. Theis JF, et al. PLoS Genet, 2010 Dec 2. PMID 21151954, Free PMC Article
  5. Functional specialisation of yeast Rho1 GTP exchange factors. Krause SA, et al. J Cell Sci, 2012 Jun 1. PMID 22344253

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
Ast2p
NP_011027.1
  • Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    360502..361794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178992.1 → NP_011027.1  TPA: Ast2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011027.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM08, P39945
    UniProtKB/TrEMBL
    C7GVH1, G2WD22, N1P594
    Conserved Domains (1) summary
    cd08247
    Location:50 → 427
    AST1_like; AST1 is a cytoplasmic protein associated with the periplasmic membrane in yeast
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39945.1

Gene LinkOut

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