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LSM4 U6 snRNA complex subunit LSM4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856848, updated on 9-Dec-2024

Summary

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Official Symbol
LSM4
Official Full Name
U6 snRNA complex subunit LSM4
Primary source
SGD:S000000914
Locus tag
YER112W
See related
AllianceGenome:SGD:S000000914; FungiDB:YER112W; VEuPathDB:YER112W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SDB23; USS1
Summary
Enables U6 snRNA binding activity. Involved in P-body assembly; cellular response to glucose starvation; and mRNA splicing, via spliceosome. Located in P-body and nucleolus. Part of Lsm1-7-Pat1 complex; sno(s)RNA-containing ribonucleoprotein complex; and spliceosomal snRNP complex. Used to study cancer. Orthologous to human LSM4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See LSM4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (387232..387795)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene karyopherin KAP123 Neighboring gene SBF complex DNA-binding subunit SWI4 Neighboring gene Tmn3p Neighboring gene Boi2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C-terminus of the yeast Lsm4p is required for the association to P-bodies. Mazzoni C, et al. FEBS Lett, 2007 Oct 16. PMID 17888427
  2. Identification and characterization of Uss1p (Sdb23p): a novel U6 snRNA-associated protein with significant similarity to core proteins of small nuclear ribonucleoproteins. Cooper M, et al. EMBO J, 1995 May 1. PMID 7744012, Free PMC Article
  3. Acetyl-L-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission. Palermo V, et al. Aging Cell, 2010 Aug. PMID 20550520
  4. Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells. Stirpe M, et al. BMC Complement Altern Med, 2017 Apr 5. PMID 28381226, Free PMC Article
  5. Isolation and study of KlLSM4, a Kluyveromyces lactis gene homologous to the essential gene LSM4 of Saccharomyces cerevisiae. Mazzoni C, et al. Yeast, 2001 Sep 30. PMID 11561292

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Subcloning analysis revealed that the Q/N-rich region of Lsm4 is responsible for the prion loss.
    Title: A bipolar functionality of Q/N-rich proteins: Lsm4 amyloid causes clearance of yeast prions.
  2. Data show that in the mRNA degradation mutant Kllsm4Delta1, histone mRNAs are induced early in the S-phase and maintained at high level all along the entire cell cycle due to a delay in the exit from S-phase and/or entry into M-phase.
    Title: Yeast lsm pro-apoptotic mutants show defects in S-phase entry and progression.
  3. Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae
    Title: Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U6 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U6 snRNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in P-body assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in P-body assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in P-body assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Lsm1-7-Pat1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U6 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of sno(s)RNA-containing ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal snRNP complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
U6 snRNA complex subunit LSM4
NP_011037.3
  • Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    387232..387795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179002.3 → NP_011037.3  TPA: U6 snRNA complex subunit LSM4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011037.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM18, P40070, Q07091
    Conserved Domains (1) summary
    cd01723
    Location:2 → 87
    LSm4; Like-Sm protein 4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40070.1

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