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SHO1 osmosensor SHO1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856854, updated on 9-Dec-2024

Summary

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Official Symbol
SHO1
Official Full Name
osmosensor SHO1
Primary source
SGD:S000000920
Locus tag
YER118C
See related
AllianceGenome:SGD:S000000920; FungiDB:YER118C; VEuPathDB:YER118C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SSU81
Summary
Enables MAP-kinase scaffold activity and osmosensor activity. Involved in establishment of cell polarity; osmosensory signaling pathway via Sho1 osmosensor; and signal transduction involved in filamentous growth. Located in cellular bud neck; mating projection tip; and plasma membrane. Part of HICS complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SHO1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (397952..399055, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene SUMO-targeted ubiquitin ligase complex subunit SLX8 Neighboring gene ribosomal 60S subunit protein L23B Neighboring gene aspartate/glutamate transporter Neighboring gene phosphatidylinositol-binding protein SCS2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Site-selective Characterization of Src Homology 3 Domain Molecular Recognition with Cyanophenylalanine Infrared Probes. Horness RE, et al. Anal Methods, 2015. PMID 26491469, Free PMC Article
  2. Candidate osmosensors from Candida utilis and Kluyveromyces lactis: structural and functional homology to the Sho1p putative osmosensor from Saccharomyces cerevisiae. Siderius M, et al. Biochim Biophys Acta, 2000 Dec 15. PMID 11118628
  3. Signal transduction: molecular monogamy. Endy D, et al. Nature, 2003 Dec 11. PMID 14668845
  4. Resolution of Site-Specific Conformational Heterogeneity in Proline-Rich Molecular Recognition by Src Homology 3 Domains. Horness RE, et al. J Am Chem Soc, 2016 Feb 3. PMID 26784847, Free PMC Article
  5. Protein-protein interaction affinity plays a crucial role in controlling the Sho1p-mediated signal transduction pathway in yeast. Marles JA, et al. Mol Cell, 2004 Jun 18. PMID 15200958

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sho1-Opy2 interaction enhances the activation of Pbs2 by Ste11, but not Hog1 by Pbs2. Chemical crosslinking and mutational analyses revealed that the cytoplasmic ends of Sho1 TM1 and Opy2 TM also interact with each other, defining the Sho1-Opy2 binding site 2 (BS2).
    Title: Interaction between the transmembrane domains of Sho1 and Opy2 enhances the signaling efficiency of the Hog1 MAP kinase cascade in Saccharomyces cerevisiae.
  2. Sho1 essential for survival under mechanical pressure.
    Title: SCWISh network is essential for survival under mechanical pressure.
  3. Fps1 binds the SH3 domain of Sho1 through its N-terminus domain and is involved in the positive regulation of Sho1p function.
    Title: A Comprehensive Membrane Interactome Mapping of Sho1p Reveals Fps1p as a Novel Key Player in the Regulation of the HOG Pathway in S. cerevisiae.
  4. Data showed that Msb2p had a function in cell polarization through the adaptor protein Sho1p that Hkr1p did not.
    Title: The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response.
  5. Hkr1 and Msb2 individually form a complex with Sho1, and, upon high external osmolarity stress, appear to induce Sho1 to generate an intracellular signal
    Title: Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.
  6. study showed that the membrane-bound osmosensor Sho1 is phosphorylated by Hog1 & that phosphorylation occurs on Ser-166; findings reveal a novel phosphorylation-dependent feedback loop leading to diminished cellular responses to an osmotic-stress stimulus
    Title: A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway.
  7. Sho1p plays role in signal transduction pathway.
    Title: Protein-protein interaction affinity plays a crucial role in controlling the Sho1p-mediated signal transduction pathway in yeast.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables MAP-kinase scaffold activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables MAP-kinase scaffold activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables osmosensor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in osmosensory signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in osmosensory signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in osmosensory signaling pathway via Sho1 osmosensor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osmosensory signaling pathway via Sho1 osmosensor IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction involved in filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of HICS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cell periphery HDA PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
osmosensor SHO1
NP_011043.1
  • Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol (HOG) response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    397952..399055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179008.1 → NP_011043.1  TPA: osmosensor SHO1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011043.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5VHP4, D3DM24, E7KBW4, E7KMS3, E7LTJ6, E7QE10, P40073
    UniProtKB/TrEMBL
    N1P521
    Conserved Domains (1) summary
    cd11855
    Location:304 → 358
    SH3_Sho1p; Src homology 3 domain of High osmolarity signaling protein Sho1p
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40073.1

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