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NSA2 rRNA-processing protein NSA2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856863, updated on 9-Dec-2024

Summary

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Official Symbol
NSA2
Official Full Name
rRNA-processing protein NSA2
Primary source
SGD:S000000928
Locus tag
YER126C
See related
AllianceGenome:SGD:S000000928; FungiDB:YER126C; VEuPathDB:YER126C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleus. Part of preribosome, large subunit precursor. Orthologous to human NSA2 (NSA2 ribosome biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NSA2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (413394..414179, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Dse1p Neighboring gene NEDD4 family E3 ubiquitin-protein ligase Neighboring gene Lcp5p Neighboring gene Vfa1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs. Lebreton A, et al. J Biol Chem, 2006 Sep 15. PMID 16861225
  2. 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Lebreton A, et al. Nucleic Acids Res, 2008 Sep. PMID 18658244, Free PMC Article
  3. Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly. Micic J, et al. Nat Commun, 2020 Jul 27. PMID 32719344, Free PMC Article
  4. The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers. Klingauf-Nerurkar P, et al. Elife, 2020 Jan 7. PMID 31909713, Free PMC Article
  5. Identification of the binding site of Rlp7 on assembling 60S ribosomal subunits in Saccharomyces cerevisiae. Dembowski JA, et al. RNA, 2013 Dec. PMID 24129494, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs
    Title: Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor HDA PubMed 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rRNA-processing protein NSA2
NP_011052.1
  • Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    413394..414179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179016.1 → NP_011052.1  TPA: rRNA-processing protein NSA2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011052.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZR80, D3DM32, P40078
    UniProtKB/TrEMBL
    B3LRP2, B5VHQ3, C7GKX3, C8Z7E3, G2WCZ9, N1P751
    Conserved Domains (1) summary
    cd11381
    Location:4 → 261
    NSA2; pre-ribosomal protein NSA2 (Nop seven-associated 2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40078.1

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