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LCP5 Lcp5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856864, updated on 9-Dec-2024

Summary

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Official Symbol
LCP5
Official Full Name
Lcp5p
Primary source
SGD:S000000929
Locus tag
YER127W
See related
AllianceGenome:SGD:S000000929; FungiDB:YER127W; VEuPathDB:YER127W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human NGDN (neuroguidin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See LCP5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (414481..415554)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene NEDD4 family E3 ubiquitin-protein ligase Neighboring gene rRNA-processing protein NSA2 Neighboring gene Vfa1p Neighboring gene serine/threonine protein kinase SAK1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation. Wiederkehr T, et al. RNA, 1998 Nov. PMID 9814757, Free PMC Article
  2. Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration. Cheng J, et al. Mol Cell, 2019 Sep 19. PMID 31378463
  3. Sgd1 is an MIF4G domain-containing cofactor of the RNA helicase Fal1 and associates with the 5' domain of the 18S rRNA sequence. Davila Gallesio J, et al. RNA Biol, 2020 Apr. PMID 31994962, Free PMC Article
  4. Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis. Billy E, et al. EMBO J, 2000 May 2. PMID 10790377, Free PMC Article
  5. Ribosome synthesis in Saccharomyces cerevisiae. Venema J, et al. Annu Rev Genet, 1999. PMID 10690410

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small nuclear ribonucleoprotein complex TAS
Traceable Author Statement
more info
 PubMed 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sno(s)RNA-containing ribonucleoprotein complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Lcp5p
NP_011053.1
  • Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    414481..415554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179017.1 → NP_011053.1  TPA: Lcp5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011053.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM33, P40079
    UniProtKB/TrEMBL
    A6ZR81, B3LRP3, C7GKX4, C8Z7E4
    Conserved Domains (1) summary
    pfam04000
    Location:8 → 108
    Sas10_Utp3; Sas10/Utp3/C1D family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40079.1

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