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GCG1 gamma-glutamylcyclotransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856910, updated on 4-Jan-2025

Summary

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Official Symbol
GCG1
Official Full Name
gamma-glutamylcyclotransferase
Primary source
SGD:S000000965
Locus tag
YER163C
See related
AllianceGenome:SGD:S000000965; FungiDB:YER163C; VEuPathDB:YER163C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables gamma-glutamylcyclotransferase activity. Involved in glutathione catabolic process. Located in cytoplasm and nucleus. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1) and CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See GCG1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (503084..503782, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Spt2p Neighboring gene Rad4p Neighboring gene chromatin-remodeling ATPase CHD1 Neighboring gene polyadenylate-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Tu BP, et al. Science, 2005 Nov 18. PMID 16254148
  2. ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione. Kaur A, et al. J Biol Chem, 2017 Jan 13. PMID 27913623, Free PMC Article
  3. Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. Kumar A, et al. EMBO Rep, 2012 Dec. PMID 23070364, Free PMC Article
  4. The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Dietrich FS, et al. Nature, 1997 May 29. PMID 9169868, Free PMC Article
  5. Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions. den Brave F, et al. Cell Rep, 2020 Jun 2. PMID 32492414, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables gamma-glutamylcyclotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione specific gamma-glutamylcyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione specific gamma-glutamylcyclotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-glutamylcyclotransferase
NP_011090.3
  • Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    503084..503782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179053.3 → NP_011090.3  TPA: gamma-glutamylcyclotransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011090.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM71, P32656
    UniProtKB/TrEMBL
    A6ZRB9, B3LRS4, C7GS47, C8Z7I5, G2WD49, N1P3P1
    Conserved Domains (1) summary
    pfam04752
    Location:8 → 231
    ChaC; ChaC-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32656.1

Gene LinkOut

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