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PLPP1 phospholipid phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 8611, updated on 27-Nov-2024

Summary

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Official Symbol
PLPP1provided by HGNC
Official Full Name
phospholipid phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:9228
See related
Ensembl:ENSG00000067113 MIM:607124; AllianceGenome:HGNC:9228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPP1; PAP2; LLP1a; PAP-2a; PPAP2A
Summary
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Expression
Broad expression in prostate (RPKM 96.2), gall bladder (RPKM 74.3) and 22 other tissues See more
Orthologs
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Genomic context

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See PLPP1 in Genome Data Viewer
Location:
5q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (55424854..55534964, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (56252163..56362555, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54720682..54830792, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Mtr4 exosome RNA helicase Neighboring gene uncharacterized LOC107986415 Neighboring gene uncharacterized LOC124900977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:54733965-54734792 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:54737283-54737821 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:54797624-54798166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:54798167-54798709 Neighboring gene microRNA 5687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22555 Neighboring gene ring finger protein 138 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:54870447-54871333 Neighboring gene adenylate kinase 4 pseudogene 2 Neighboring gene uncharacterized LOC124900980 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:54899656-54900855

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate. Yamanaka M, et al. Biochem Biophys Res Commun, 2008 Oct 31. PMID 18755152
  2. Molecular characterization of the type 2 phosphatidic acid phosphatase. Kanoh H, et al. Chem Phys Lipids, 1999 Apr. PMID 10358934
  3. The first transmembrane domain of lipid phosphatase SAC1 promotes Golgi localization. Wang J, et al. PLoS One, 2013. PMID 23936490, Free PMC Article
  4. Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators. Roberts RZ, et al. Biochim Biophys Acta, 2000 Aug 24. PMID 10962286
  5. Roles of phosphatidate phosphatase enzymes in lipid metabolism. Carman GM, et al. Trends Biochem Sci, 2006 Dec. PMID 17079146, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the first of the two transmembrane regions in human SAC1 (TM1) functions in Golgi localization
    Title: The first transmembrane domain of lipid phosphatase SAC1 promotes Golgi localization.
  2. Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association
    Title: Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. These results suggest that LPP1a is important for the determination of plasma FTY720-P levels.
    Title: A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate.
  5. Lipopolysaccharide-induced up-regulation of cyclooxygenase-2 depends on the activity of the Mg(+2)-dependent phosphatidic acid phosphohydrolase 1 (PAP-1)
    Title: Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent.
  6. This protein and phosphoprotein SET regulate androgen production by P450c17.
    Title: Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17.
  7. These results suggest that the expression of PAP2a is directly regulated by p73.
    Title: The expression of phosphatidic acid phosphatase 2a, which hydrolyzes lipids to generate diacylglycerol, is regulated by p73, a member of the p53 family.
  8. this enzyme regulates interleukin-4-mediated STAT6 signaling.
    Title: Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling.
  9. lipid phosphate phosphatase-1 has a role in regulating accumulation of lysophosphatidic acid in ovarian cancer
    Title: Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
  10. LPP1 and LPP3 are distributed in distinct lipid rafts that may provide unique microenvironments defining their non-redundant physiological functions.
    Title: Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ceramide-1-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diacylglycerol diphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lipid phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophosphatidic acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidate phosphatase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sphingosine-1-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sphingosine-1-phosphate phosphatase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nuclear receptor-mediated steroid hormone signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid dephosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lipid metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid catabolic process TAS
Traceable Author Statement
more info
  
involved_in sphingosine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in caveola ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
phospholipid phosphatase 1
Names
lipid phosphate phosphohydrolase 1a
phosphatidate phosphohydrolase type 2a
phosphatidic acid phosphatase 2a
phosphatidic acid phosphatase type 2A
phosphatidic acid phosphohydrolase type 2a
type-2 phosphatidic acid phosphatase alpha
NP_003702.2
NP_795714.1
XP_006714787.1
XP_054209713.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003711.4 → NP_003702.2  phospholipid phosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_003702.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also named PAP2-a1) lacks an alternate exon and contains an in-frame alternate exon in the 5' coding region, compared to variant 2. The resulting isoform (1) contains a distinct internal segment and is shorter, compared to isoform 2.
    Source sequence(s)
    AF014402, BC008787, BC039847, BC143281
    Consensus CDS
    CCDS34159.1
    UniProtKB/Swiss-Prot
    B7ZKN8, G3XA95, O14494, O60457, O60463, Q17RZ4
    Related
    ENSP00000302229.8, ENST00000307259.9
    Conserved Domains (1) summary
    cd03384
    Location:98 → 243
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  2. NM_176895.3 → NP_795714.1  phospholipid phosphatase 1 isoform 2

    See identical proteins and their annotated locations for NP_795714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also named PAP2-a2) encodes the longer isoform (2).
    Source sequence(s)
    AF014403, BC008787, BC039847, BC168254
    Consensus CDS
    CCDS34160.1
    Related
    ENSP00000264775.5, ENST00000264775.9
    Conserved Domains (1) summary
    cd03384
    Location:99 → 244
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RNA

  1. NR_103485.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF014402, BC008787, BC039847, BC168254

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    55424854..55534964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714724.4 → XP_006714787.1  phospholipid phosphatase 1 isoform X1

    Conserved Domains (1) summary
    cd03384
    Location:35 → 180
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    56252163..56362555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353738.1 → XP_054209713.1  phospholipid phosphatase 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14494.1 GenPept UniProtKB/Swiss-Prot:O14494

Gene LinkOut

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