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EIF4G3 eukaryotic translation initiation factor 4 gamma 3 [ Homo sapiens (human) ]

Gene ID: 8672, updated on 27-Nov-2024

Summary

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Official Symbol
EIF4G3provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4 gamma 3provided by HGNC
Primary source
HGNC:HGNC:3298
See related
Ensembl:ENSG00000075151 MIM:603929; AllianceGenome:HGNC:3298
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eIF4G 3; eIF4GII; eIF-4G 3
Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Expression
Broad expression in testis (RPKM 35.2), thyroid (RPKM 16.6) and 23 other tissues See more
Orthologs
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Genomic context

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See EIF4G3 in Genome Data Viewer
Location:
1p36.12
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20806292..21176897, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (20632859..21003583, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (21132785..21503390, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21054065-21054727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21054728-21055389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21056983-21057676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21057677-21058368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21058590-21059262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21059263-21059933 Neighboring gene SH2 domain containing 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21112523-21112715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 376 Neighboring gene heterochromatin protein 1 binding protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21146362-21146862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21146863-21147363 Neighboring gene RNA, U7 small nuclear 200 pseudogene Neighboring gene uncharacterized LOC105376830 Neighboring gene uncharacterized LOC105376829 Neighboring gene NFE2L2 motif-containing MPRA enhancer 38 Neighboring gene Sharpr-MPRA regulatory region 2723 Neighboring gene microRNA 1256 Neighboring gene ribosomal protein S15a pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21394491-21394661 Neighboring gene MPRA-validated peak106 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 325 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 27 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21544531-21544736 Neighboring gene MPRA-validated peak108 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21562319-21562819 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:21587933-21589132 Neighboring gene uncharacterized LOC124903872 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21591626-21592452 Neighboring gene Sharpr-MPRA regulatory region 15718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21600579-21601078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21603224-21604202 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:21604203-21605179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21610131-21610992 Neighboring gene endothelin converting enzyme 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21615400-21615961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 326 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:21620661-21621860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21623064-21623668 Neighboring gene ECE1 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. Gradi A, et al. J Virol, 2003 Apr. PMID 12663812, Free PMC Article
  2. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Gingras AC, et al. Annu Rev Biochem, 1999. PMID 10872469
  3. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. Gradi A, et al. J Virol, 2004 Apr. PMID 15016848, Free PMC Article
  4. Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII. Miura T, et al. J Biomol NMR, 2003 Nov. PMID 12975586
  5. Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335. Wang Q, et al. Pathol Res Pract, 2019 Sep. PMID 31257089

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our study demonstrates that circ-EIF4G3 promotes the proliferation, invasion and migration of gastric cancer via sponging miR-335.
    Title: Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at 1p36 are associated with superior frontal gyrus volume.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA cap binding TAS
Traceable Author Statement
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation factor activity, RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of translational initiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in intracellular membraneless organelle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 4 gamma 3
Names
eIF-4-gamma 3
eIF-4-gamma II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047026.1 RefSeqGene

    Range
    5424..375842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198801.2 → NP_001185730.1  eukaryotic translation initiation factor 4 gamma 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB209119, AL031005, BC072413, BC094683, BF084093, CN402454
    Consensus CDS
    CCDS72723.1
    UniProtKB/TrEMBL
    A0A0A0MSA7, A0A8I5KT99
    Related
    ENSP00000383274.2, ENST00000400422.6

  2. NM_001198802.2 → NP_001185731.1  eukaryotic translation initiation factor 4 gamma 3 isoform 2

    See identical proteins and their annotated locations for NP_001185731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional in-frame smaller exon in the 5' coding region and lacks an in-frame larger exon in the middle coding region, as compared to variant 1. The resulting isoform (2) has an extra smaller segment in one region and lacks a larger segment in another region, as compared to isoform 1.
    Source sequence(s)
    AB209119, AL031005, BC072413, BC094683, BF084093, CN402454
    Consensus CDS
    CCDS55580.1
    UniProtKB/TrEMBL
    A0A8I5KT99
    Related
    ENSP00000509941.1, ENST00000686579.1
    Conserved Domains (5) summary
    cd11559
    Location:1434 → 1562
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:27 → 302
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1228 → 1340
    MA3; MA3 domain
    pfam02854
    Location:761 → 989
    MIF4G; MIF4G domain
    cl17013
    Location:1541 → 1587
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  3. NM_001198803.2 → NP_001185732.1  eukaryotic translation initiation factor 4 gamma 3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR and an additional in-frame exon in the 5' coding region, and lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (4) has an extra internal segment and a distinct and much shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL358392, AL627311, BC030578
    Consensus CDS
    CCDS59192.1
    UniProtKB/Swiss-Prot
    O43432
    Related
    ENSP00000507819.1, ENST00000682284.1

  4. NM_001391892.1 → NP_001378821.1  eukaryotic translation initiation factor 4 gamma 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    Consensus CDS
    CCDS214.1
    UniProtKB/Swiss-Prot
    B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1428 → 1556
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:10 → 296
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1222 → 1334
    MA3; MA3 domain
    pfam02854
    Location:755 → 983
    MIF4G; MIF4G domain
    cl17013
    Location:1535 → 1581
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  5. NM_001391893.1 → NP_001378822.1  eukaryotic translation initiation factor 4 gamma 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    Consensus CDS
    CCDS214.1
    UniProtKB/Swiss-Prot
    B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
    UniProtKB/TrEMBL
    A0A8I5KT99
    Related
    ENSP00000264211.7, ENST00000264211.13
    Conserved Domains (5) summary
    cd11559
    Location:1428 → 1556
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:10 → 296
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1222 → 1334
    MA3; MA3 domain
    pfam02854
    Location:755 → 983
    MIF4G; MIF4G domain
    cl17013
    Location:1535 → 1581
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  6. NM_001391894.1 → NP_001378823.1  eukaryotic translation initiation factor 4 gamma 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    Consensus CDS
    CCDS214.1
    UniProtKB/Swiss-Prot
    B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1428 → 1556
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:10 → 296
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1222 → 1334
    MA3; MA3 domain
    pfam02854
    Location:755 → 983
    MIF4G; MIF4G domain
    cl17013
    Location:1535 → 1581
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  7. NM_001391895.1 → NP_001378824.1  eukaryotic translation initiation factor 4 gamma 3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL627311
    UniProtKB/TrEMBL
    B4DXR2

  8. NM_001391896.1 → NP_001378825.1  eukaryotic translation initiation factor 4 gamma 3 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1427 → 1506
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:10 → 295
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1221 → 1333
    MA3; MA3 domain
    pfam02854
    Location:754 → 982
    MIF4G; MIF4G domain
    cl17013
    Location:1484 → 1533
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  9. NM_001391897.1 → NP_001378826.1  eukaryotic translation initiation factor 4 gamma 3 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1379 → 1507
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam05109
    Location:107 → 322
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02847
    Location:1173 → 1285
    MA3; MA3 domain
    pfam02854
    Location:706 → 934
    MIF4G; MIF4G domain
    cl17013
    Location:1486 → 1532
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  10. NM_001391898.1 → NP_001378827.1  eukaryotic translation initiation factor 4 gamma 3 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1439 → 1518
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:4 → 307
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1233 → 1345
    MA3; MA3 domain
    pfam02854
    Location:766 → 994
    MIF4G; MIF4G domain
    cl17013
    Location:1496 → 1545
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  11. NM_001391899.1 → NP_001378828.1  eukaryotic translation initiation factor 4 gamma 3 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1427 → 1555
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:10 → 295
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1221 → 1333
    MA3; MA3 domain
    pfam02854
    Location:754 → 982
    MIF4G; MIF4G domain
    cl17013
    Location:1534 → 1580
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  12. NM_001391900.1 → NP_001378829.1  eukaryotic translation initiation factor 4 gamma 3 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    UniProtKB/TrEMBL
    A0A8I5KT99
    Related
    ENSP00000489051.2, ENST00000634879.2
    Conserved Domains (5) summary
    cd11559
    Location:1427 → 1555
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:10 → 295
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1221 → 1333
    MA3; MA3 domain
    pfam02854
    Location:754 → 982
    MIF4G; MIF4G domain
    cl17013
    Location:1534 → 1580
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  13. NM_001391901.1 → NP_001378830.1  eukaryotic translation initiation factor 4 gamma 3 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1435 → 1563
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:6 → 334
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:1229 → 1341
    MA3; MA3 domain
    pfam02854
    Location:762 → 990
    MIF4G; MIF4G domain
    cl17013
    Location:1542 → 1588
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  14. NM_001391902.1 → NP_001378831.1  eukaryotic translation initiation factor 4 gamma 3 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1465 → 1593
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:58 → 333
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1259 → 1371
    MA3; MA3 domain
    pfam02854
    Location:792 → 1020
    MIF4G; MIF4G domain
    cl17013
    Location:1572 → 1618
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  15. NM_001391903.1 → NP_001378832.1  eukaryotic translation initiation factor 4 gamma 3 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1465 → 1593
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:58 → 333
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1259 → 1371
    MA3; MA3 domain
    pfam02854
    Location:792 → 1020
    MIF4G; MIF4G domain
    cl17013
    Location:1572 → 1618
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  16. NM_001391904.1 → NP_001378833.1  eukaryotic translation initiation factor 4 gamma 3 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1465 → 1593
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:10 → 296
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1259 → 1371
    MA3; MA3 domain
    pfam02854
    Location:792 → 1020
    MIF4G; MIF4G domain
    cl17013
    Location:1572 → 1618
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  17. NM_001391905.1 → NP_001378834.1  eukaryotic translation initiation factor 4 gamma 3 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    Consensus CDS
    CCDS90875.1
    UniProtKB/TrEMBL
    A0A8I5KT99, A0A8I5QJH9
    Related
    ENSP00000509547.1, ENST00000688741.1
    Conserved Domains (5) summary
    cd11559
    Location:1476 → 1604
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1270 → 1382
    MA3; MA3 domain
    pfam02854
    Location:803 → 1031
    MIF4G; MIF4G domain
    pfam03154
    Location:53 → 368
    Atrophin-1; Atrophin-1 family
    cl17013
    Location:1583 → 1629
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  18. NM_001391906.1 → NP_001378835.1  eukaryotic translation initiation factor 4 gamma 3 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    Consensus CDS
    CCDS90876.1
    UniProtKB/TrEMBL
    A0A8I5KT99, A0A8J9G7U8
    Related
    ENSP00000473510.2, ENST00000602326.6
    Conserved Domains (5) summary
    cd11559
    Location:1484 → 1612
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:52 → 383
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:1278 → 1390
    MA3; MA3 domain
    pfam02854
    Location:811 → 1039
    MIF4G; MIF4G domain
    cl17013
    Location:1591 → 1637
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  19. NM_001391907.1 → NP_001378836.1  eukaryotic translation initiation factor 4 gamma 3 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL031005, AL358392, AL606477, AL627311
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1514 → 1642
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1308 → 1420
    MA3; MA3 domain
    pfam02854
    Location:841 → 1069
    MIF4G; MIF4G domain
    pfam03154
    Location:53 → 369
    Atrophin-1; Atrophin-1 family
    cl17013
    Location:1621 → 1667
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  20. NM_003760.4 → NP_003751.2  eukaryotic translation initiation factor 4 gamma 3 isoform 3

    See identical proteins and their annotated locations for NP_003751.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AB209119, AF012072, BC094683, BF084093
    Consensus CDS
    CCDS214.1
    UniProtKB/Swiss-Prot
    B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1
    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1428 → 1556
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:10 → 296
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1222 → 1334
    MA3; MA3 domain
    pfam02854
    Location:755 → 983
    MIF4G; MIF4G domain
    cl17013
    Location:1535 → 1581
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    20806292..21176897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433321.1 → XP_047289277.1  eukaryotic translation initiation factor 4 gamma 3 isoform X29

  2. XM_047433366.1 → XP_047289322.1  eukaryotic translation initiation factor 4 gamma 3 isoform X42

  3. XM_047433324.1 → XP_047289280.1  eukaryotic translation initiation factor 4 gamma 3 isoform X31

  4. XM_017002708.3 → XP_016858197.1  eukaryotic translation initiation factor 4 gamma 3 isoform X41

    UniProtKB/TrEMBL
    B4DH17
    Related
    ENSP00000364071.3, ENST00000374935.7
    Conserved Domains (4) summary
    cd11559
    Location:1148 → 1276
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:942 → 1054
    MA3; MA3 domain
    pfam02854
    Location:475 → 703
    MIF4G; MIF4G domain
    cl17013
    Location:1255 → 1301
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  5. XM_017002707.3 → XP_016858196.1  eukaryotic translation initiation factor 4 gamma 3 isoform X40

    UniProtKB/TrEMBL
    B4DZE1
    Conserved Domains (4) summary
    cd11559
    Location:1185 → 1313
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:979 → 1091
    MA3; MA3 domain
    pfam02854
    Location:512 → 740
    MIF4G; MIF4G domain
    cl17013
    Location:1292 → 1338
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  6. XM_047433340.1 → XP_047289296.1  eukaryotic translation initiation factor 4 gamma 3 isoform X34

  7. XM_011542370.3 → XP_011540672.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

    See identical proteins and their annotated locations for XP_011540672.1

    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1521 → 1649
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PHA03247
    Location:52 → 383
    PHA03247; large tegument protein UL36; Provisional
    pfam02847
    Location:1315 → 1427
    MA3; MA3 domain
    pfam02854
    Location:848 → 1076
    MIF4G; MIF4G domain
    cl17013
    Location:1628 → 1674
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  8. XM_047433231.1 → XP_047289187.1  eukaryotic translation initiation factor 4 gamma 3 isoform X7

    Related
    ENSP00000509442.1, ENST00000685872.1

  9. XM_047433319.1 → XP_047289275.1  eukaryotic translation initiation factor 4 gamma 3 isoform X28

    UniProtKB/Swiss-Prot
    B9EGQ7, O43432, Q15597, Q504Z1, Q5SWC3, Q8NEN1

  10. XM_047433196.1 → XP_047289152.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

  11. XM_047433323.1 → XP_047289279.1  eukaryotic translation initiation factor 4 gamma 3 isoform X30

  12. XM_047433348.1 → XP_047289304.1  eukaryotic translation initiation factor 4 gamma 3 isoform X36

  13. XM_047433337.1 → XP_047289293.1  eukaryotic translation initiation factor 4 gamma 3 isoform X33

  14. XM_047433345.1 → XP_047289301.1  eukaryotic translation initiation factor 4 gamma 3 isoform X35

  15. XM_047433329.1 → XP_047289285.1  eukaryotic translation initiation factor 4 gamma 3 isoform X32

  16. XM_047433291.1 → XP_047289247.1  eukaryotic translation initiation factor 4 gamma 3 isoform X22

    UniProtKB/TrEMBL
    A0A0A0MSA7

  17. XM_047433287.1 → XP_047289243.1  eukaryotic translation initiation factor 4 gamma 3 isoform X21

  18. XM_047433312.1 → XP_047289268.1  eukaryotic translation initiation factor 4 gamma 3 isoform X26

    Conserved Domains (5) summary
    cd11559
    Location:1434 → 1562
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:27 → 302
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1228 → 1340
    MA3; MA3 domain
    pfam02854
    Location:761 → 989
    MIF4G; MIF4G domain
    cl17013
    Location:1541 → 1587
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  19. XM_047433274.1 → XP_047289230.1  eukaryotic translation initiation factor 4 gamma 3 isoform X17

  20. XM_047433296.1 → XP_047289252.1  eukaryotic translation initiation factor 4 gamma 3 isoform X24

  21. XM_047433294.1 → XP_047289250.1  eukaryotic translation initiation factor 4 gamma 3 isoform X23

  22. XM_011542371.3 → XP_011540673.1  eukaryotic translation initiation factor 4 gamma 3 isoform X12

    See identical proteins and their annotated locations for XP_011540673.1

    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1476 → 1604
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    PRK10263
    Location:4 → 307
    PRK10263; DNA translocase FtsK; Provisional
    pfam02847
    Location:1270 → 1382
    MA3; MA3 domain
    pfam02854
    Location:803 → 1031
    MIF4G; MIF4G domain
    cl17013
    Location:1583 → 1629
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  23. XM_047433261.1 → XP_047289217.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

    UniProtKB/TrEMBL
    A0A804HJV5
    Related
    ENSP00000507662.1, ENST00000684485.1

  24. XM_047433283.1 → XP_047289239.1  eukaryotic translation initiation factor 4 gamma 3 isoform X20

  25. XM_047433282.1 → XP_047289238.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

  26. XM_017002677.3 → XP_016858166.1  eukaryotic translation initiation factor 4 gamma 3 isoform X6

    UniProtKB/TrEMBL
    A0A8I5KT99
    Conserved Domains (5) summary
    cd11559
    Location:1503 → 1631
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1297 → 1409
    MA3; MA3 domain
    pfam02854
    Location:830 → 1058
    MIF4G; MIF4G domain
    pfam11235
    Location:202 → 330
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    cl17013
    Location:1610 → 1656
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

  27. XM_047433268.1 → XP_047289224.1  eukaryotic translation initiation factor 4 gamma 3 isoform X15

  28. XM_047433267.1 → XP_047289223.1  eukaryotic translation initiation factor 4 gamma 3 isoform X14

  29. XM_047433212.1 → XP_047289168.1  eukaryotic translation initiation factor 4 gamma 3 isoform X5

  30. XM_047433205.1 → XP_047289161.1  eukaryotic translation initiation factor 4 gamma 3 isoform X4

  31. XM_047433201.1 → XP_047289157.1  eukaryotic translation initiation factor 4 gamma 3 isoform X3

  32. XM_047433354.1 → XP_047289310.1  eukaryotic translation initiation factor 4 gamma 3 isoform X39

  33. XM_047433315.1 → XP_047289271.1  eukaryotic translation initiation factor 4 gamma 3 isoform X27

  34. XM_047433253.1 → XP_047289209.1  eukaryotic translation initiation factor 4 gamma 3 isoform X9

  35. XM_047433279.1 → XP_047289235.1  eukaryotic translation initiation factor 4 gamma 3 isoform X18

  36. XM_047433198.1 → XP_047289154.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

  37. XM_047433353.1 → XP_047289309.1  eukaryotic translation initiation factor 4 gamma 3 isoform X38

  38. XM_047433352.1 → XP_047289308.1  eukaryotic translation initiation factor 4 gamma 3 isoform X37

  39. XM_047433302.1 → XP_047289258.1  eukaryotic translation initiation factor 4 gamma 3 isoform X25

  40. XM_047433242.1 → XP_047289198.1  eukaryotic translation initiation factor 4 gamma 3 isoform X8

    UniProtKB/TrEMBL
    A0A8J9G7U8

  41. XM_047433269.1 → XP_047289225.1  eukaryotic translation initiation factor 4 gamma 3 isoform X16

  42. XM_047433266.1 → XP_047289222.1  eukaryotic translation initiation factor 4 gamma 3 isoform X13

  43. XM_047433262.1 → XP_047289218.1  eukaryotic translation initiation factor 4 gamma 3 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    20632859..21003583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339387.1 → XP_054195362.1  eukaryotic translation initiation factor 4 gamma 3 isoform X31

  2. XM_054339394.1 → XP_054195369.1  eukaryotic translation initiation factor 4 gamma 3 isoform X40

  3. XM_054339390.1 → XP_054195365.1  eukaryotic translation initiation factor 4 gamma 3 isoform X34

  4. XM_054339357.1 → XP_054195332.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

  5. XM_054339361.1 → XP_054195336.1  eukaryotic translation initiation factor 4 gamma 3 isoform X43

  6. XM_054339376.1 → XP_054195351.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

  7. XM_054339369.1 → XP_054195344.1  eukaryotic translation initiation factor 4 gamma 3 isoform X13

  8. XM_054339381.1 → XP_054195356.1  eukaryotic translation initiation factor 4 gamma 3 isoform X23

  9. XM_054339365.1 → XP_054195340.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

    UniProtKB/TrEMBL
    A0A804HJV5

  10. XM_054339368.1 → XP_054195343.1  eukaryotic translation initiation factor 4 gamma 3 isoform X44

    UniProtKB/TrEMBL
    A0A8I5QJH9

  11. XM_054339366.1 → XP_054195341.1  eukaryotic translation initiation factor 4 gamma 3 isoform X11

  12. XM_054339353.1 → XP_054195328.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

  13. XM_054339386.1 → XP_054195361.1  eukaryotic translation initiation factor 4 gamma 3 isoform X30

  14. XM_054339389.1 → XP_054195364.1  eukaryotic translation initiation factor 4 gamma 3 isoform X33

  15. XM_054339388.1 → XP_054195363.1  eukaryotic translation initiation factor 4 gamma 3 isoform X32

  16. XM_054339379.1 → XP_054195354.1  eukaryotic translation initiation factor 4 gamma 3 isoform X22

    UniProtKB/TrEMBL
    A0A0A0MSA7

  17. XM_054339378.1 → XP_054195353.1  eukaryotic translation initiation factor 4 gamma 3 isoform X21

  18. XM_054339384.1 → XP_054195359.1  eukaryotic translation initiation factor 4 gamma 3 isoform X26

  19. XM_054339373.1 → XP_054195348.1  eukaryotic translation initiation factor 4 gamma 3 isoform X17

  20. XM_054339382.1 → XP_054195357.1  eukaryotic translation initiation factor 4 gamma 3 isoform X24

  21. XM_054339380.1 → XP_054195355.1  eukaryotic translation initiation factor 4 gamma 3 isoform X23

  22. XM_054339367.1 → XP_054195342.1  eukaryotic translation initiation factor 4 gamma 3 isoform X12

  23. XM_054339364.1 → XP_054195339.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

    UniProtKB/TrEMBL
    A0A804HJV5

  24. XM_054339377.1 → XP_054195352.1  eukaryotic translation initiation factor 4 gamma 3 isoform X20

  25. XM_054339360.1 → XP_054195335.1  eukaryotic translation initiation factor 4 gamma 3 isoform X43

  26. XM_054339375.1 → XP_054195350.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

  27. XM_054339359.1 → XP_054195334.1  eukaryotic translation initiation factor 4 gamma 3 isoform X6

  28. XM_054339371.1 → XP_054195346.1  eukaryotic translation initiation factor 4 gamma 3 isoform X15

  29. XM_054339370.1 → XP_054195345.1  eukaryotic translation initiation factor 4 gamma 3 isoform X14

  30. XM_054339358.1 → XP_054195333.1  eukaryotic translation initiation factor 4 gamma 3 isoform X5

  31. XM_054339356.1 → XP_054195331.1  eukaryotic translation initiation factor 4 gamma 3 isoform X4

  32. XM_054339355.1 → XP_054195330.1  eukaryotic translation initiation factor 4 gamma 3 isoform X3

  33. XM_054339393.1 → XP_054195368.1  eukaryotic translation initiation factor 4 gamma 3 isoform X39

  34. XM_054339385.1 → XP_054195360.1  eukaryotic translation initiation factor 4 gamma 3 isoform X27

  35. XM_054339363.1 → XP_054195338.1  eukaryotic translation initiation factor 4 gamma 3 isoform X9

  36. XM_054339374.1 → XP_054195349.1  eukaryotic translation initiation factor 4 gamma 3 isoform X18

  37. XM_054339354.1 → XP_054195329.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

  38. XM_054339392.1 → XP_054195367.1  eukaryotic translation initiation factor 4 gamma 3 isoform X38

  39. XM_054339391.1 → XP_054195366.1  eukaryotic translation initiation factor 4 gamma 3 isoform X37

  40. XM_054339383.1 → XP_054195358.1  eukaryotic translation initiation factor 4 gamma 3 isoform X25

  41. XM_054339362.1 → XP_054195337.1  eukaryotic translation initiation factor 4 gamma 3 isoform X8

    UniProtKB/TrEMBL
    A0A8J9G7U8

  42. XM_054339372.1 → XP_054195347.1  eukaryotic translation initiation factor 4 gamma 3 isoform X16

  43. XM_054339352.1 → XP_054195327.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43432.2 GenPept UniProtKB/Swiss-Prot:O43432

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