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CG42638 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 8673965, updated on 4-Jan-2025

Summary

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Official Symbol
CG42638provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0261361
Locus tag
Dmel_CG42638
See related
AllianceGenome:FB:FBgn0261361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG42638; noncoding_13567
Summary
Enables intracellularly ligand-gated monoatomic ion channel activity; monoatomic cation channel activity; and phosphatidylinositol-3,5-bisphosphate binding activity. Involved in several processes, including autophagosome maturation; positive regulation of TOR signaling; and positive regulation of synaptic assembly at neuromuscular junction. Located in endolysosome membrane; late endosome membrane; and plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in Lisch epithelial corneal dystrophy; glycoproteinosis; and mucolipidosis type IV. Orthologous to human MCOLN1 (mucolipin TRP cation channel 1); MCOLN2 (mucolipin TRP cation channel 2); and MCOLN3 (mucolipin TRP cation channel 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CG42638 in Genome Data Viewer
Location:
76C3-76C3; 3-46 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19745834..19749744, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19738934..19742844, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Transient receptor potential cation channel, mucolipin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Guanylyl cyclase at 76C Neighboring gene Viral tegument-like deubiquitinase Neighboring gene Sterol regulatory element binding protein Neighboring gene mir-33 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. Feng X, et al. J Biol Chem, 2014 Feb 14. PMID 24375408, Free PMC Article
  2. Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells. Venkatachalam K, et al. Cell, 2008 Nov 28. PMID 19041749, Free PMC Article
  3. Drosophila TRPML is required for TORC1 activation. Wong CO, et al. Curr Biol, 2012 Sep 11. PMID 22863314, Free PMC Article
  4. Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. Wong CO, et al. Cell Rep, 2015 Sep 29. PMID 26387958, Free PMC Article
  5. Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages. Wong CO, et al. Cell Host Microbe, 2017 Jun 14. PMID 28579255, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NAADP-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly ligand-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic cation transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cation channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endolysosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG42638-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19745834..19749744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170001.2 → NP_001163472.1  uncharacterized protein Dmel_CG42638 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163472.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW35
    Conserved Domains (1) summary
    pfam00520
    Location:403 → 578
    Ion_trans; Ion transport protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VW35 Q9VW35

Gene LinkOut

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