U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nost Nostrin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 8673992, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Nostprovided by FlyBase
Official Full Name
Nostrinprovided by FlyBase
Primary source
FLYBASE:FBgn0259734
Locus tag
Dmel_CG42388
See related
AllianceGenome:FB:FBgn0259734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15364; CG33224; CG4040; CG42388; Dmel\CG42388; nost; NOSTRIN
Old locus tag
CG4040; Dmel_CG15364; Dmel_CG33224; Dmel_CG4040
Summary
Enables lipid binding activity. Involved in epithelial cell differentiation; plasma membrane tubulation; and regulation of adherens junction organization. Located in endosome. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic hypopharynx; germline cell; and gut section. Orthologous to human NOSTRIN (nitric oxide synthase trafficking). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nost in Genome Data Viewer
Location:
8C3-8C4; 1-26 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9030205..9054575)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8924238..8948608)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene retinal degeneration A Neighboring gene long non-coding RNA:CR43836 Neighboring gene uncharacterized protein Neighboring gene mir-31b stem loop Neighboring gene antisense RNA:CR45538 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RNAi Screen in Tribolium Reveals Involvement of F-BAR Proteins in Myoblast Fusion and Visceral Muscle Morphogenesis in Insects. Schultheis D, et al. G3 (Bethesda), 2019 Apr 9. PMID 30733382, Free PMC Article
  2. Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in the regulation of E-cadherin in epithelial morphogenesis. Zobel T, et al. J Cell Sci, 2015 Feb 1. PMID 25413347
  3. Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis. Takeda T, et al. Open Biol, 2013 Aug 7. PMID 23926047, Free PMC Article
  4. Adherens Junctions on the Move-Membrane Trafficking of E-Cadherin. Brüser L, et al. Cold Spring Harb Perspect Biol, 2017 Mar 1. PMID 28096264, Free PMC Article
  5. Fusion pore dynamics of large secretory vesicles define a distinct mechanism of exocytosis. Biton T, et al. J Cell Biol, 2023 Nov 6. PMID 37707500, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in germarium-derived female germ-line cyst encapsulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in imaginal disc-derived wing hair organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in plasma membrane organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in plasma membrane tubulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of adherens junction organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nostrin
Names
CG42388-PC
CG42388-PD
CG42388-PE
CG42388-PF
CG42388-PG
CG42388-PH
Nost-PC
Nost-PD
Nost-PE
Nost-PF
Nost-PG
Nost-PH

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9030205..9054575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298100.1 → NP_001285029.1  nostrin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285029.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JAX8
    Conserved Domains (2) summary
    cd07658
    Location:663 → 908
    F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
    cd11823
    Location:1276 → 1328
    SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

  2. NM_001201637.1 → NP_001188566.1  nostrin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188566.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP19, H1UUM2
    Conserved Domains (2) summary
    cd07658
    Location:103 → 346
    F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
    cd11823
    Location:714 → 766
    SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

  3. NM_132287.3 → NP_572515.2  nostrin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572515.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MQH0, Q7K115
    Conserved Domains (2) summary
    cd07658
    Location:9 → 253
    F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
    cd11823
    Location:621 → 673
    SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

  4. NM_001169241.1 → NP_001162712.1  nostrin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162712.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5SHR1, Q7K115
    Conserved Domains (2) summary
    cd07658
    Location:6 → 249
    F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
    cd11823
    Location:617 → 669
    SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

  5. NM_001201638.2 → NP_001188567.1  nostrin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188567.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJS0
    Conserved Domains (2) summary
    cd07658
    Location:558 → 803
    F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
    cd11823
    Location:1171 → 1223
    SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer

  6. NM_001169240.2 → NP_001162711.1  nostrin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162711.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJS0
    Conserved Domains (2) summary
    cd07658
    Location:558 → 803
    F-BAR_NOSTRIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
    cd11823
    Location:1171 → 1223
    SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5RJS0 B5RJS0
D5SHR1 D5SHR1
H1UUM2 H1UUM2
M9MQH0 M9MQH0
Q7K115 Q7K115
X2JAX8 X2JAX8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools