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mgl - Megalin

Predicted to enable hormone binding activity. Involved in chitin-based cuticle development; regulation of adult chitin-containing cuticle pigmentation; and regulation of endocytosis. Located in apical plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; anterior-posterior subdivision of organism; epithelium; extraembryonic structure; and gut section. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa