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OtopLa Otopetrin-like a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 8674066, updated on 9-Dec-2024

Summary

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Official Symbol
OtopLaprovided by FlyBase
Official Full Name
Otopetrin-like aprovided by FlyBase
Primary source
FLYBASE:FBgn0259994
Locus tag
Dmel_CG42492
See related
AllianceGenome:FB:FBgn0259994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.181; CG11473; CG17761; CG42492; Dmel\CG42492; dmOTOPLa; dm_OtopLa; otopla; OtopLA
Old locus tag
Dmel_CG11473; Dmel_CG17761
Summary
Enables proton channel activity and sour taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of sour taste and proton transmembrane transport. Is active in plasma membrane. Is expressed in adult head. Orthologous to human OTOP1 (otopetrin 1); OTOP2 (otopetrin 2); and OTOP3 (otopetrin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See OtopLa in Genome Data Viewer
Location:
5A8-5A9; 1-12 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5625676..5648487, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5519709..5542520, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Myosin light chain cytoplasmic Neighboring gene mir-3645 stem loop Neighboring gene POP1 ribonuclease P/MRP subunit Neighboring gene Otopetrin-like c Neighboring gene antisense RNA:CR45520 Neighboring gene Sirtuin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular and cellular basis of acid taste sensation in Drosophila. Mi T, et al. Nat Commun, 2021 Jun 17. PMID 34140480, Free PMC Article
  2. Requirement for an Otopetrin-like protein for acid taste in Drosophila. Ganguly A, et al. Proc Natl Acad Sci U S A, 2021 Dec 21. PMID 34911758, Free PMC Article
  3. Acid and Alkali Taste Sensation. Pandey P, et al. Metabolites, 2023 Nov 4. PMID 37999227, Free PMC Article
  4. Tastant-receptor interactions: insights from the fruit fly. Arntsen C, et al. Front Nutr, 2024. PMID 38665300, Free PMC Article
  5. An evolutionarily conserved gene family encodes proton-selective ion channels. Tu YH, et al. Science, 2018 Mar 2. PMID 29371428, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Requirement for an Otopetrin-like protein for acid taste in Drosophila.
    Title: Requirement for an Otopetrin-like protein for acid taste in Drosophila.
  2. Molecular and cellular basis of acid taste sensation in Drosophila.
    Title: Molecular and cellular basis of acid taste sensation in Drosophila.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables proton channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton channel activity IEA
Inferred from Electronic Annotation
more info
  
enables sour taste receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in detection of chemical stimulus involved in sensory perception of sour taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Otopetrin-like a
Names
CG42492-PA
CG42492-PC
CG42492-PD
CG42492-PE
CG42492-PF
CG42492-PG
OtopLa-PA
OtopLa-PC
OtopLa-PD
OtopLa-PE
OtopLa-PF
OtopLa-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5625676..5648487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272326.1 → NP_001259255.1  Otopetrin-like a, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259255.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8K1YXJ9, M9PJ56
    Conserved Domains (1) summary
    pfam03189
    Location:663 → 960
    Otopetrin; Otopetrin

  2. NM_001272325.1 → NP_001259254.1  Otopetrin-like a, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259254.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8K1YXJ9, M9PGQ4
    Conserved Domains (1) summary
    pfam03189
    Location:661 → 958
    Otopetrin; Otopetrin

  3. NM_132009.4 → NP_572237.1  Otopetrin-like a, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572237.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8K1YXJ9, Q9W4A6
    Conserved Domains (1) summary
    pfam03189
    Location:604 → 897
    Otopetrin; Otopetrin

  4. NM_001272328.1 → NP_001259257.1  Otopetrin-like a, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259257.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8K1YXJ9, M9PGH2
    Conserved Domains (1) summary
    pfam03189
    Location:642 → 939
    Otopetrin; Otopetrin

  5. NM_001272327.1 → NP_001259256.1  Otopetrin-like a, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259256.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8K1YXJ9, M9PDU2
    Conserved Domains (1) summary
    pfam03189
    Location:642 → 909
    Otopetrin; Otopetrin

  6. NM_001169205.2 → NP_001162676.1  Otopetrin-like a, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162676.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DNA0, E1JJE6
    Conserved Domains (1) summary
    pfam03189
    Location:679 → 972
    Otopetrin; Otopetrin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JJE6 E1JJE6
M9PDU2 M9PDU2
M9PGH2 M9PGH2
M9PGQ4 M9PGQ4
M9PJ56 M9PJ56
Q9W4A6 Q9W4A6

Gene LinkOut

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