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MARCO macrophage receptor with collagenous structure [ Homo sapiens (human) ]

Gene ID: 8685, updated on 27-Nov-2024

Summary

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Official Symbol
MARCOprovided by HGNC
Official Full Name
macrophage receptor with collagenous structureprovided by HGNC
Primary source
HGNC:HGNC:6895
See related
Ensembl:ENSG00000019169 MIM:604870; AllianceGenome:HGNC:6895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR-A6; SCARA2
Summary
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung (RPKM 74.5), appendix (RPKM 41.8) and 3 other tissues See more
Orthologs
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Genomic context

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See MARCO in Genome Data Viewer
Location:
2q14.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (118942194..118994660)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119375479..119427929)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (119699770..119752236)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119590580-119591348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119599819-119600399 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:119602243-119602892 and GRCh37_chr2:119602893-119603542 Neighboring gene long intergenic non-protein coding RNA 1956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119607811-119608363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119610971-119611506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119615003-119615764 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119615765-119616526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119616527-119617286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11898 Neighboring gene engrailed homeobox 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:119671170-119672369 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:119711468-119712667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119746563-119747064 Neighboring gene uncharacterized LOC124906072 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:119749973-119751172 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:119807422-119808621 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:119843263-119843429 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:119868745-119869944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119870527-119871192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119891922-119892422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119892423-119892923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119914695-119915505 Neighboring gene RNA, 7SL, cytoplasmic 468, pseudogene Neighboring gene complement C1q like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Down-regulation of MARCO associates with tumor progression in hepatocellular carcinoma. Xiao Y, et al. Exp Cell Res, 2019 Oct 15. PMID 31381879
  2. A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function. Novakowski KE, et al. Immunol Cell Biol, 2016 Aug. PMID 26888252, Free PMC Article
  3. DNA Microarray Analysis of Submandibular Glands in IgG4-Related Disease Indicates a Role for MARCO and Other Innate Immune-Related Proteins. Ohta M, et al. Medicine (Baltimore), 2016 Feb. PMID 26886650, Free PMC Article
  4. Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma. Sun H, et al. J Gastroenterol Hepatol, 2017 May. PMID 27806438
  5. Genetic variation in the scavenger receptor MARCO and its association with chronic obstructive pulmonary disease and lung infection in 10,604 individuals. Thomsen M, et al. Respiration, 2013. PMID 23154236

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression.
    Title: Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression.
  2. Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics.
    Title: Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics.
  3. TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
    Title: TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
  4. Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.
    Title: Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.
  5. Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells.
    Title: Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells.
  6. Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.
    Title: Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.
  7. Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.
    Title: Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.
  8. Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.
    Title: Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.
  9. Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
    Title: Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
  10. MARCO is involved in hepatocellular carcinoma (HCC)progression and it can be defined as a novel probable biomarker as well as treatment target for HCC.
    Title: Down-regulation of MARCO associates with tumor progression in hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr potentiates the stimulation of macrophage receptor with collagenous structure by glucocorticoids via the glucocorticoid receptor pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables G protein-coupled receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cargo receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables pattern recognition receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic cell clearance IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
macrophage receptor MARCO
Names
scavenger receptor class A, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006770.4 → NP_006761.1  macrophage receptor MARCO

    See identical proteins and their annotated locations for NP_006761.1

    Status: REVIEWED

    Source sequence(s)
    AC013457
    Consensus CDS
    CCDS2124.1
    UniProtKB/Swiss-Prot
    B4DW79, Q9UEW3, Q9Y5S3
    UniProtKB/TrEMBL
    B4DLJ6, Q4ZG40
    Related
    ENSP00000318916.4, ENST00000327097.5
    Conserved Domains (2) summary
    pfam01391
    Location:286 → 344
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:424 → 519
    SR; Scavenger receptor Cys-rich

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    118942194..118994660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512082.3 → XP_011510384.1  macrophage receptor MARCO isoform X1

    See identical proteins and their annotated locations for XP_011510384.1

    UniProtKB/Swiss-Prot
    B4DW79, Q9UEW3, Q9Y5S3
    UniProtKB/TrEMBL
    B4DLJ6, Q4ZG40
    Conserved Domains (2) summary
    pfam01391
    Location:286 → 344
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:424 → 519
    SR; Scavenger receptor Cys-rich

  2. XM_011512083.4 → XP_011510385.1  macrophage receptor MARCO isoform X2

    Conserved Domains (3) summary
    pfam01391
    Location:165 → 223
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:303 → 398
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:308 → 398
    SRCR; Scavenger receptor cysteine-rich domain

  3. XM_017005171.3 → XP_016860660.1  macrophage receptor MARCO isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    119375479..119427929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344329.1 → XP_054200304.1  macrophage receptor MARCO isoform X1

    UniProtKB/Swiss-Prot
    B4DW79, Q9UEW3, Q9Y5S3
    UniProtKB/TrEMBL
    Q4ZG40

  2. XM_054344330.1 → XP_054200305.1  macrophage receptor MARCO isoform X2

  3. XM_054344331.1 → XP_054200306.1  macrophage receptor MARCO isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UEW3.1 GenPept UniProtKB/Swiss-Prot:Q9UEW3

Gene LinkOut

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