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thiL thiamine monophosphate kinase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 878642, updated on 24-Aug-2024

Summary

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Gene symbol
thiL
Gene description
thiamine monophosphate kinase
Locus tag
PA4051
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (4532653..4533621, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene phosphatidylglycerophosphatase A Neighboring gene transcription antitermination protein NusB Neighboring gene 6,7-dimethyl-8-ribityllumazine synthase Neighboring gene 3,4-dihydroxy-2-butanone-4-phosphate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ThiL enzyme is a valid antibacterial target essential for both thiamine biosynthesis and salvage pathways in Pseudomonas aeruginosa. Kim HJ, et al. J Biol Chem, 2020 Jul 17. PMID 32404369, Free PMC Article
  2. Characterization of thiL, encoding thiamin-monophosphate kinase, in Salmonella typhimurium. Webb E, et al. J Biol Chem, 1997 Jun 20. PMID 9188462
  3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
  5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ThiL enzyme is a valid antibacterial target essential for both thiamine biosynthesis and salvage pathways in Pseudomonas aeruginosa.
    Title: The ThiL enzyme is a valid antibacterial target essential for both thiamine biosynthesis and salvage pathways in Pseudomonas aeruginosa.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables thiamine-phosphate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
thiamine monophosphate kinase
NP_252740.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    4532653..4533621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_252740.1 thiamine monophosphate kinase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_252740.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9HWX7
    Conserved Domains (1) summary
    PRK05731
    Location:1 → 317
    PRK05731; thiamine monophosphate kinase; Provisional
Nucleotide Protein
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Gene LinkOut

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