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hemO heme oxygenase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 880820, updated on 11-Sep-2024

Summary

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Gene symbol
hemO
Gene description
heme oxygenase
Locus tag
PA0672
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (732959..733555)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene error-prone DNA polymerase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ECF sigma factor VreI

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The heme-binding protein PhuS transcriptionally regulates the Pseudomonas aeruginosa tandem sRNA prrF1,F2 locus. Wilson T, et al. J Biol Chem, 2021 Jan-Jun. PMID 33428928, Free PMC Article
  2. Biochemical characterization of biliverdins IXβ/δ generated by a selective heme oxygenase. Zhang B, et al. Biochem J, 2020 Feb 14. PMID 31913441
  3. Ligand-induced allostery in the interaction of the Pseudomonas aeruginosa heme binding protein with heme oxygenase. Deredge DJ, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28289188, Free PMC Article
  4. Metabolite-driven Regulation of Heme Uptake by the Biliverdin IXβ/δ-Selective Heme Oxygenase (HemO) of Pseudomonas aeruginosa. Mouriño S, et al. J Biol Chem, 2016 Sep 23. PMID 27493207, Free PMC Article
  5. Metabolic flux of extracellular heme uptake in Pseudomonas aeruginosa is driven by the iron-regulated heme oxygenase (HemO). Barker KD, et al. J Biol Chem, 2012 May 25. PMID 22493498, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The heme-binding protein PhuS transcriptionally regulates the Pseudomonas aeruginosa tandem sRNA prrF1,F2 locus.
    Title: The heme-binding protein PhuS transcriptionally regulates the Pseudomonas aeruginosa tandem sRNA prrF1,F2 locus.
  2. Authors exploited the unique capacity of the Pseudomonas aeruginosa hemO/pigA gene for focused generation of isomeric biliverdinss (IXbeta and IXdelta).
    Title: Biochemical characterization of biliverdins IXβ/δ generated by a selective heme oxygenase.
  3. The PhuS N-terminal alpha1/alpha2-helices that are cooperatively linked to the motions of the C-terminal domain also map to the PhuS:HemO interface.
    Title: Ligand-induced allostery in the interaction of the Pseudomonas aeruginosa heme binding protein with heme oxygenase.
  4. coupling the PhuS-dependent flux of heme through HemO to feedback regulation of the cell surface signaling system through HasA allows P. aeruginosa to rapidly respond to fluctuating extracellular heme levels independent of the iron status of the cell.
    Title: Metabolite-driven Regulation of Heme Uptake by the Biliverdin IXβ/δ-Selective Heme Oxygenase (HemO) of Pseudomonas aeruginosa.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
acts_upstream_of_or_within heme oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
heme oxygenase
NP_249363.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    732959..733555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249363.1 heme oxygenase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249363.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    G3XCZ8, O69002
    Conserved Domains (2) summary
    COG3230
    Location:4 → 198
    HemO; Heme oxygenase [Inorganic ion transport and metabolism]
    cd00232
    Location:110 → 135
    HemeO-like; kinked helix [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3XCZ8.1

Gene LinkOut

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Molecular Biology Databases