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mvaT transcriptional regulator MvaT [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 881542, updated on 24-Aug-2024

Summary

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Gene symbol
mvaT
Gene description
transcriptional regulator MvaT
Locus tag
PA4315
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (4843812..4844186)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene formyltetrahydrofolate deformylase Neighboring gene exonuclease I Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. H-NS-like proteins in Pseudomonas aeruginosa coordinately silence intragenic transcription. Lippa AM, et al. Mol Microbiol, 2021 Jun. PMID 33245158, Free PMC Article
  2. Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins. Qin L, et al. Nucleic Acids Res, 2020 Feb 28. PMID 31925429, Free PMC Article
  3. mvaT mutation modifies the expression of the Pseudomonas aeruginosa multidrug efflux operon mexEF-oprN. Westfall LW, et al. FEMS Microbiol Lett, 2006 Feb. PMID 16448502
  4. H-NS family members function coordinately in an opportunistic pathogen. Castang S, et al. Proc Natl Acad Sci U S A, 2008 Dec 2. PMID 19028873, Free PMC Article
  5. The multifaceted proteins MvaT and MvaU, members of the H-NS family, control arginine metabolism, pyocyanin synthesis, and prophage activation in Pseudomonas aeruginosa PAO1. Li C, et al. J Bacteriol, 2009 Oct. PMID 19684136, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The horizontal transfer of Pseudomonas aeruginosa PA14 ICE PAPI-1 is controlled by a transcriptional triad between TprA, NdpA2 and MvaT.
    Title: The horizontal transfer of Pseudomonas aeruginosa PA14 ICE PAPI-1 is controlled by a transcriptional triad between TprA, NdpA2 and MvaT.
  2. Novel anti-repression mechanism of H-NS proteins by a phage protein.
    Title: Novel anti-repression mechanism of H-NS proteins by a phage protein.
  3. H-NS-like proteins in Pseudomonas aeruginosa coordinately silence intragenic transcription.
    Title: H-NS-like proteins in Pseudomonas aeruginosa coordinately silence intragenic transcription.
  4. Pseudomonas aeruginosa quorum sensing system repressor was highly upregulated with mvaT mvaU double knockout in mice system. Hence, the synthesis of pyocyanin was suffocated and the biofilm formation ability was decreased.
    Title: Mechanism of pyocyanin abolishment caused by mvaT mvaU double knockout in Pseudomonas aeruginosa PAO1.
  5. In this study, the histone-like proteins MvaT and MvaU are added to the growing list of global regulators that control the type III secretion system the primary effect of MvaT/MvaU on T3SS gene expression is through direct silencing of the P exsA promoter.
    Title: H-NS Family Members MvaT and MvaU Regulate the Pseudomonas aeruginosa Type III Secretion System.
  6. This switching is a direct effect of ionic strength on electrostatic interactions between the oppositely charged DNA binding and N-terminal domains of MvaT. The asymmetric charge distribution and intramolecular interactions are conserved among the H-NS family of proteins.
    Title: Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins.
  7. we have characterized the DNA sequences preferentially targeted by MvaT, and identified differences in sequence preferences between MvaT and other xenogeneic silencers
    Title: A Novel AT-Rich DNA Recognition Mechanism for Bacterial Xenogeneic Silencer MvaT.
  8. These findings suggest that type IV pili are the receptors for Pf4 phage and that the essential activities of MvaT and MvaU are to repress the expression of Pf4 genes.
    Title: Basis for the essentiality of H-NS family members in Pseudomonas aeruginosa.
  9. These findings support a model in which the ability of MvaT to bind efficiently to the DNA depends upon protein-protein interactions between MvaT dimers.
    Title: High-order oligomerization is required for the function of the H-NS family member MvaT in Pseudomonas aeruginosa.
  10. Depletion of MvaT and MvaU had serious effects on a variety of physiological functions in P. aeruginosa.
    Title: The multifaceted proteins MvaT and MvaU, members of the H-NS family, control arginine metabolism, pyocyanin synthesis, and prophage activation in Pseudomonas aeruginosa PAO1.
Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of secondary metabolite biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of single-species biofilm formation on inanimate substrate IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
transcriptional regulator MvaT
NP_253005.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    4843812..4844186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_253005.1 transcriptional regulator MvaT [Pseudomonas aeruginosa PAO1]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q9HW86
    Conserved Domains (2) summary
    cd16170
    Location:80 → 121
    MvaT_DBD; DNA-binding domain of the bacterial xenogeneic silencer MvaT
    NF033551
    Location:11 → 75
    transpos_IS1182; IS1182 family transposase
Nucleotide Protein
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