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mctB copper transporter MctB [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885047, updated on 6-Oct-2023

Summary

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Gene symbol
mctB
Gene description
copper transporter MctB
Locus tag
Rv1698
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1922745..1923689)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene DNA repair protein RecN Neighboring gene hypothetical protein Neighboring gene CTP synthase Neighboring gene NUDIX hydrolase Neighboring gene tyrosine recombinase XerD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, expression, purification, crystallization and preliminary crystallographic analysis of Rv1698, an outer membrane channel protein from Mycobacterium tuberculosis. Chen L, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Nov 1. PMID 21045312, Free PMC Article
  2. Rv1698 of Mycobacterium tuberculosis represents a new class of channel-forming outer membrane proteins. Siroy A, et al. J Biol Chem, 2008 Jun 27. PMID 18434314, Free PMC Article
  3. Copper resistance is essential for virulence of Mycobacterium tuberculosis. Wolschendorf F, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21205886, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies indicate that mutant lacking the outer membrane channel protein Rv1698 accumulated 100-fold more Cu and was more susceptible to Cu toxicity than WT.
    Title: Copper resistance is essential for virulence of Mycobacterium tuberculosis.
  2. crystals of Rv1698 diffracted to 2.5 A resolution and belonged to the orthorhombic space group P422, with unit-cell parameters a = b = 122.0, c = 88.9 A
    Title: Cloning, expression, purification, crystallization and preliminary crystallographic analysis of Rv1698, an outer membrane channel protein from Mycobacterium tuberculosis.
  3. Rv1698 is a channel protein that is likely involved in transport processes across the outer membrane of M. tuberculosis
    Title: Rv1698 of Mycobacterium tuberculosis represents a new class of channel-forming outer membrane proteins.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
copper transporter MctB
NP_216214.1
  • mycobacterial copper transport protein B essential for Cu resistance and maintenance of low intracellular Cu levels A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1922745..1923689
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216214.1 copper transporter MctB [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216214.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3L967
    Conserved Domains (1) summary
    pfam11382
    Location:10 → 312
    MctB; Copper transport outer membrane protein, MctB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJ83.1

Gene LinkOut

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