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Rv0888 hypothetical protein [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885210, updated on 6-Oct-2023

Summary

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Gene symbol
Rv0888
Gene description
hypothetical protein
Locus tag
Rv0888
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (987233..988705)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene ferredoxin/ferredoxin--NADP reductase Neighboring gene hypothetical protein Neighboring gene citrate synthase 2 Neighboring gene HTH-type transcriptional regulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps. Dang G, et al. Front Immunol, 2018. PMID 29670633, Free PMC Article
  2. Characterization of Rv0888, a Novel Extracellular Nuclease from Mycobacterium tuberculosis. Dang G, et al. Sci Rep, 2016 Jan 8. PMID 26742696, Free PMC Article
  3. Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages. Speer A, et al. Mol Microbiol, 2015 Sep. PMID 26036301, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that extracellular sphingomyelinase Rv0888 of Mycobacterium tuberculosis contributes to pathological lung injury of Mycobacterium smegmatis in mice via Inducing formation of neutrophil extracellular traps
    Title: Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps.
  2. Mycobacterium tuberculosis Rv0888 is a novel extracellular nuclease and a virulence factor.
    Title: Characterization of Rv0888, a Novel Extracellular Nuclease from Mycobacterium tuberculosis.
  3. Rv0888 is a novel outer membrane protein that enables Mycobacterium tuberculosis to utilize sphingomyelin as a source of several essential nutrients during intracellular growth
    Title: Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
hypothetical protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    987233..988705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215403.1 hypothetical protein Rv0888 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215403.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7W4X5
    Conserved Domains (2) summary
    pfam17963
    Location:104 → 186
    Big_9; Bacterial Ig domain
    cl00490
    Location:343 → 478
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WKQ1.1

Gene LinkOut

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