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glcB malate synthase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885713, updated on 4-Feb-2024

Summary

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Gene symbol
glcB
Gene description
malate synthase
Locus tag
Rv1837c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2084756..2086981, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene serine esterase Neighboring gene hypothetical protein Neighboring gene ribonuclease VapC13 Neighboring gene PE-PGRS family protein PE_PGRS34 Neighboring gene antitoxin VapB13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The product complex of M. tuberculosis malate synthase revisited. Anstrom DM, et al. Protein Sci, 2006 Aug. PMID 16877713, Free PMC Article
  2. Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis. Achkar JM, et al. Clin Vaccine Immunol, 2006 Nov. PMID 17090645, Free PMC Article
  3. Detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children. Haldar S, et al. PLoS One, 2012. PMID 22984534, Free PMC Article
  4. Mycobacterium tuberculosis malate synthase is a laminin-binding adhesin. Kinhikar AG, et al. Mol Microbiol, 2006 May. PMID 16677310
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. description of how detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children
    Title: Detection of Mycobacterium tuberculosis GlcB or HspX Antigens or devR DNA impacts the rapid diagnosis of tuberculous meningitis in children.
  2. The revised position of bound malate is consistent with a reaction mechanism that does not require reorientation of the electrophilic substrate during the catalytic cycle, while the revised Mg(++) coordination is octahedral
    Title: The product complex of M. tuberculosis malate synthase revisited.
  3. Malate synthase- and MPT51-based serologic test serves as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.
    Title: Mycobacterium tuberculosis malate synthase- and MPT51-based serodiagnostic assay as an adjunct to rapid identification of pulmonary tuberculosis.
  4. Mycobacterium tuberculosis malate synthase (MS) has adapted to function as an adhesin which binds to laminin and fibronectin.
    Title: Mycobacterium tuberculosis malate synthase is a laminin-binding adhesin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
malate synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2084756..2086981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216353.1 malate synthase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216353.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A654TMV3
    Conserved Domains (1) summary
    PRK02999
    Location:1 → 726
    PRK02999; malate synthase G; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5H8P_A.1
5H8U_A.1
5H8U_B.1
P9WK17.1

Gene LinkOut

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