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espJ ESX-1 secretion-associated protein EspJ [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886198, updated on 6-Aug-2024

Summary

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Gene symbol
espJ
Gene description
ESX-1 secretion-associated protein EspJ
Locus tag
Rv3878
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
TB27.4
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Genomic context

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Sequence:
NC_000962.3 (4356693..4357535)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene ESAT-6 protein EsxA Neighboring gene ESX-1 secretion-associated protein EspI Neighboring gene ESX-1 secretion system protein EccD1 Neighboring gene ESX-1 secretion-associated protein EspK Neighboring gene ESX-1 secretion-associated protein EspL Neighboring gene ESX-1 secretion-associated protein EspB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria. Singh PK, et al. Sci Rep, 2015 Jul 31. PMID 26228622, Free PMC Article
  2. Conserved alanine rich protein Rv3878 in Mycobacterium tuberculosis contains sequence polymorphisms. Jiang Y, et al. Tuberculosis (Edinb), 2014 May. PMID 24674998
  3. [Application of T cell responses to novel RD1-encoded mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection]. Liu XQ. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2008 Jun. PMID 18686610
  4. Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator. Abdallah AM, et al. PLoS One, 2019. PMID 30673778, Free PMC Article
  5. A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. McLaughlin B, et al. PLoS Pathog, 2007 Aug 3. PMID 17676952, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these data show that WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates and that ESX-1 substrates are regulated independently from the structural components, both during infection and as a result of active secretion.
    Title: Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator.
  2. EspJ protein gets phosph.orylated prior to affect the growth and intracellular survival of Mycobacterium tuberculosis.
    Title: RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria.
  3. The results show that Rv3878 is conserved in M Tuberc and contains polymorphisms which may reflect ongoing immune evasion
    Title: Conserved alanine rich protein Rv3878 in Mycobacterium tuberculosis contains sequence polymorphisms.
  4. The T cell response rates to Rv3873, Rv3878, and Rv3879c were 53% (95% CI: 39%-67%), 35% (95% CI: 22%-48%), and 45% (95% CI: 31%-57%), respectively, in the TB group and were 7.9%, 2.6%, and 2.6%, respectively, in the control group.
    Title: [Application of T cell responses to novel RD1-encoded mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection].
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General gene information

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Homology

General protein information

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Preferred Names
ESX-1 secretion-associated protein EspJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4356693..4357535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218395.1 ESX-1 secretion-associated protein EspJ [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218395.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WJC3
    UniProtKB/TrEMBL
    I6YD92
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJC3.1

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