U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gyrA DNA gyrase subunit A [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887105, updated on 4-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
gyrA
Gene description
DNA gyrase subunit A
Locus tag
Rv0006
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000962.3 (7302..9818)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene DNA replication/repair protein RecF Neighboring gene hypothetical protein Neighboring gene DNA gyrase subunit B Neighboring gene membrane protein Neighboring gene tRNA-Ile

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Specific gyrA Gene Mutations Correlate with High Prevalence of Discordant Levofloxacin Resistance in Mycobacterium tuberculosis Isolates from Beijing, China. Huo F, et al. J Mol Diagn, 2020 Sep. PMID 32619641
  2. Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients. Kabir S, et al. BMC Pulm Med, 2020 May 11. PMID 32393213, Free PMC Article
  3. The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA). Huang YY, et al. Nucleic Acids Res, 2006. PMID 17038336, Free PMC Article
  4. Dynamics of fluoroquinolones induced resistance in DNA gyrase of Mycobacterium tuberculosis. Pandey B, et al. J Biomol Struct Dyn, 2018 Feb. PMID 28071975
  5. Purification, crystallization and preliminary X-ray diffraction experiments on the breakage-reunion domain of the DNA gyrase from Mycobacterium tuberculosis. Piton J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Nov 1. PMID 19923746, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Characteristic of Both Levofloxacin and Moxifloxacin Resistance in Mycobacterium tuberculosis from Individuals Diagnosed with Preextensive Drug-Resistant Tuberculosis.
    Title: Molecular Characteristic of Both Levofloxacin and Moxifloxacin Resistance in Mycobacterium tuberculosis from Individuals Diagnosed with Preextensive Drug-Resistant Tuberculosis.
  2. Specific gyrA Gene Mutations Correlate with High Prevalence of Discordant Levofloxacin Resistance in Mycobacterium tuberculosis Isolates from Beijing, China.
    Title: Specific gyrA Gene Mutations Correlate with High Prevalence of Discordant Levofloxacin Resistance in Mycobacterium tuberculosis Isolates from Beijing, China.
  3. Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients.
    Title: Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients.
  4. Structure-based molecular docking of complex comprised of DNA bound with Gyrase A (large subunit) and Gyrase C (small subunit) with moxifloxacin (MFX) revealed high binding affinity to wild type with considerably high Glide XP docking score of -7.88 kcal/mol
    Title: Dynamics of fluoroquinolones induced resistance in DNA gyrase of Mycobacterium tuberculosis.
  5. The double mutants GyrA(A90V) GyrB(D500N) and GyrA(A90V) GyrB(T539N) are reported to be implicated in conferring higher levels of OFX resistance.
    Title: Double Mutants in DNA Gyrase Lead to Ofloxacin Resistance in Mycobacterium tuberculosis.
  6. At a given locus, topoisomerase I and DNA gyrase were localized behind and ahead of RNAP, respectively, correlating with the twin-supercoiled domains generated. The recruitment of topoisomerases was higher at the genomic loci with higher transcriptional activity and/or at regions under high torsional stress compared to silent genomic loci
    Title: Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase.
  7. Mutations in gyrA and gyrB among fuoroquinolone- and multidrug-resistant Mycobacterium tuberculosis Isolates have been described.
    Title: Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates.
  8. gyrA mutations are associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis.
    Title: Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: a systematic review.
  9. First evaluation of drug-resistant Mycobacterium tuberculosis clinical isolates from Congo revealed misdetection of fluoroquinolone resistance by line probe assay due to a double substitution T80A-A90G in GyrA.
    Title: First evaluation of drug-resistant Mycobacterium tuberculosis clinical isolates from Congo revealed misdetection of fluoroquinolone resistance by line probe assay due to a double substitution T80A-A90G in GyrA.
  10. The gyrA mutations at codons 90, 91 and 94 constitute the primary mechanism of fluoroquinolone resistance in Mycobacterium tuberculosis, and mutations at codon 91 in the gyrA gene may be associated with low-level resistance to ofloxacin.
    Title: Characterization of gyrA and gyrB mutations and fluoroquinolone resistance in Mycobacterium tuberculosis clinical isolates from Hubei Province, China.
Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
DNA gyrase subunit A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    7302..9818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214520.1 DNA gyrase subunit A [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214520.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    J9VB15, P71574, P97136, P9WG46, Q07702
    UniProtKB/TrEMBL
    A0A2R4IPX3, H9N0J7, H9N0L4, H9N0M3, H9N0M9
    Conserved Domains (2) summary
    sd00041
    Location:515 → 562
    GyrA-ParC_C; GyrA_CTD repeat [structural motif]
    NF038098
    Location:130 → 824
    GyrA_w_intein; intein-containing DNA gyrase subunit A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WG47.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials