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tcrA two component DNA binding transcriptional regulator TcrA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887870, updated on 10-Oct-2024

Summary

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Gene symbol
tcrA
Gene description
two component DNA binding transcriptional regulator TcrA
Locus tag
Rv0602c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (699038..699799, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene two component sensor kinase HK1 Neighboring gene two component sensor kinase HK2 Neighboring gene hypothetical protein Neighboring gene lipoprotein LpqO

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intra- and intermolecular domain interactions among novel two-component system proteins coded by Rv0600c, Rv0601c and Rv0602c of Mycobacterium tuberculosis. Shrivastava R, et al. Microbiology (Reading), 2009 Mar. PMID 19246748
  2. Probing the nucleotide binding and phosphorylation by the histidine kinase of a novel three-protein two-component system from Mycobacterium tuberculosis. Shrivastava R, et al. FEBS Lett, 2007 May 1. PMID 17434492
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TcrA interacted well with HK2 but not with HK1.
    Title: Intra- and intermolecular domain interactions among novel two-component system proteins coded by Rv0600c, Rv0601c and Rv0602c of Mycobacterium tuberculosis.
  2. A new mode of interaction for phosphotransfer between the two-component system proteins in bacteria.
    Title: Probing the nucleotide binding and phosphorylation by the histidine kinase of a novel three-protein two-component system from Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
two component DNA binding transcriptional regulator TcrA
NP_215116.1
  • This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    699038..699799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215116.1 two component DNA binding transcriptional regulator TcrA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215116.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3M2M6, A0A679LBH5
    Conserved Domains (1) summary
    COG0745
    Location:24 → 246
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O07776.1

Gene LinkOut

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