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whiB1 transcriptional regulator WhiB1 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887980, updated on 29-Jan-2021

Summary

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Gene symbol
whiB1
Gene description
transcriptional regulator WhiB1
Locus tag
Rv3219
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
whmE
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Genomic context

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Sequence:
NC_000962.3 (3595713..3595967)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene integral membrane protein Neighboring gene hypothetical protein Neighboring gene two component sensor kinase Neighboring gene acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis of non-canonical transcriptional regulation by the σA-bound iron-sulfur protein WhiB1 in M. tuberculosis. Wan T, et al. Nucleic Acids Res, 2020 Jan 24. PMID 31807774, Free PMC Article
  2. Structure of a Wbl protein and implications for NO sensing by M. tuberculosis. Kudhair BK, et al. Nat Commun, 2017 Dec 22. PMID 29273788, Free PMC Article
  3. Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis. Raju RM, et al. PLoS Pathog, 2014 Mar. PMID 24603869, Free PMC Article
  4. Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1. Smith LJ, et al. PLoS One, 2012. PMID 22792304, Free PMC Article
  5. Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster. Smith LJ, et al. Biochem J, 2010 Dec 15. PMID 20929442, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results demonstrate that holo-WhiB1 regulates gene expression by a non-canonical mechanism relative to well-characterized sigma A4-dependent transcription activators
    Title: Structural basis of non-canonical transcriptional regulation by the σA-bound iron-sulfur protein WhiB1 in M. tuberculosis.
  2. NMR structural model of WhiB1 reveals that Wbl proteins are four-helix bundles with a core of three alpha-helices held together by a [4Fe-4S] cluster. The WhiB1 structure suggests that loss of the iron-sulfur cluster (by nitrosylation) permits positively charged residues in the C-terminal helix to engage in DNA binding, triggering a major reprogramming of gene expression that includes components of the ESX-1 secretion ...
    Title: Structure of a Wbl protein and implications for NO sensing by M. tuberculosis.
  3. we were able to unambiguously identify WhiB1, an essential transcriptional repressor capable of auto-repression, as a substrate of the mycobacterial Clp protease.
    Title: Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis.
  4. Analysis of the C-terminal region of WhiB1 revealed the crucial roles played by a predicted beta-turn and two conserved positively-charged motifs in facilitating DNA-binding, but not iron-sulfur cluster acquisition.
    Title: Structure-function relationships of the Mycobacterium tuberculosis transcription factor WhiB1.
  5. Data suggest whiB1 (with [4Fe-4S] cluster) is activated in presence of nitric oxide allowing whiB1 to bind to DNA (at region overlapping core promoter elements).
    Title: Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
transcriptional regulator WhiB1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3595713..3595967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217735.1 transcriptional regulator WhiB1 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217735.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WF43
    UniProtKB/TrEMBL
    I6X6Q4
    Conserved Domains (1) summary
    pfam02467
    Location:3 → 70
    Whib; Transcription factor WhiB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WF43.1

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