U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rv3377c type B diterpene cyclase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888073, updated on 6-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
Rv3377c
Gene description
type B diterpene cyclase
Locus tag
Rv3377c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000962.3 (3790848..3792353, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene amidase Neighboring gene phosphatase Neighboring gene diterpene synthase Neighboring gene 1-deoxy-D-xylulose-5-phosphate synthase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c. Zhang Y, et al. Biochemistry, 2020 Dec 1. PMID 33182997, Free PMC Article
  2. Characterization and inhibition of a class II diterpene cyclase from Mycobacterium tuberculosis: implications for tuberculosis. Mann FM, et al. J Biol Chem, 2009 Aug 28. PMID 19574210, Free PMC Article
  3. Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton. Nakano C, et al. Chem Commun (Camb), 2005 Feb 28. PMID 15719101
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c.
    Title: Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c.
  2. Class II diterpene cyclase catalyzes the committed step in edaxadiene biosynthesis.
    Title: Characterization and inhibition of a class II diterpene cyclase from Mycobacterium tuberculosis: implications for tuberculosis.
  3. gene encodes the diterpene cyclase for producing (+)-5(6),13-halimadiene-15-ol, which accepts geranylgeranyldiphosphate as intrinsic substrate
    Title: Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
type B diterpene cyclase
NP_217894.1
  • This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187). Cofactor: Mg2+.

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3790848..3792353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217894.1 type B diterpene cyclase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217894.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WCI0
    Conserved Domains (2) summary
    PLN02592
    Location:17 → 325
    PLN02592; ent-copalyl diphosphate synthase
    cd00688
    Location:269 → 473
    ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O50406.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases