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vapC21 ribonuclease VapC21 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888249, updated on 6-Oct-2023

Summary

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Gene symbol
vapC21
Gene description
ribonuclease VapC21
Locus tag
Rv2757c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3070170..3070586, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene thymidylate synthase ThyX Neighboring gene type I restriction/modification system DNA methylase HsdM Neighboring gene antitoxin VapB21 Neighboring gene ribonuclease VapC42 Neighboring gene antitoxin VapB42 Neighboring gene type I restriction/modification system specificity determinant HsdS Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of VapC21 from Mycobacterium tuberculosis at 1.31 Å resolution. Jardim P, et al. Biochem Biophys Res Commun, 2016 Sep 23. PMID 27576202
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VapC21 is a dimer in solution, with conserved active site architecture and an extensive antitoxin binding groove.
    Title: Crystal structure of VapC21 from Mycobacterium tuberculosis at 1.31 Å resolution.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
ribonuclease VapC21
NP_217273.1
  • toxin, part of toxin-antitoxin (TA) operon with Rv2758c,contains PIN domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3070170..3070586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217273.1 ribonuclease VapC21 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217273.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WB33, R4M8U6
    Conserved Domains (1) summary
    cd18755
    Location:6 → 133
    PIN_MtVapC3_VapC21-like; VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WF91.1

Gene LinkOut

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