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mapB methionine aminopeptidase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888596, updated on 4-Feb-2024

Summary

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Gene symbol
mapB
Gene description
methionine aminopeptidase
Locus tag
Rv2861c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
map
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Genomic context

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Sequence:
NC_000962.3 (3173160..3174017, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 3-oxoacyl-ACP reductase Neighboring gene aldehyde dehydrogenase AldC Neighboring gene glutamine amidotransferase Neighboring gene glutamine synthetase Neighboring gene hypothetical protein Neighboring gene antitoxin VapB23 Neighboring gene ribonuclease VapC23

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents. Reddi R, et al. FEBS J, 2014 Sep. PMID 24841365
  2. Biochemical characterization of recombinant methionine aminopeptidases (MAPs) from Mycobacterium tuberculosis H37Rv. Narayanan SS, et al. Mol Cell Biochem, 2012 Jun. PMID 22466806
  3. Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37Rv. Zhang X, et al. Curr Microbiol, 2009 Nov. PMID 19688379
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metal ions in the active site of Mycobacterium tuberculosis methionine aminopeptidase assist in the covalent modification of Cys105 by orienting the reagents appropriately for a successful reaction.
    Title: Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents.
  2. Cobalt and nickel are activators of MtbMAP A and MtbMAP B while magnesium was not, site directed mutagenesis also revealed key residues in binding of the metal ions were also identified for both enzymes.
    Title: Biochemical characterization of recombinant methionine aminopeptidases (MAPs) from Mycobacterium tuberculosis H37Rv.
  3. MapA and MapB have different activities in their substrate specificity, divalent ion requirement, and optimal temperature.
    Title: Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37Rv.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
methionine aminopeptidase
YP_177911.1
  • map (peptidase M)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3173160..3174017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177911.1 methionine aminopeptidase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177911.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WAS4
    Conserved Domains (1) summary
    PRK12896
    Location:33 → 283
    PRK12896; methionine aminopeptidase; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WK19.1

Gene LinkOut

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