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Envelope surface glycoprotein gp120
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env
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Cell-cell contact between T cells expressing HIV-1 gp120/gp41 and other T cells expressing CD4 receptors leads to the rapid accumulation of cyclin B and tyrosine-hyperphosphorylated p34cdc2 (cdk1) kinase, indicative of cell cycle arrest at G2 phase |
PubMed
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Tat
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tat
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HIV-1 Tat stimulates polyubiquitination-mediated degradation of cyclin B1 through binding to the N-terminal of cyclin B1 (amino acids 61-129) that is just downstream of the D box |
PubMed
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tat
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HIV-1 Tat forms a quaternary complex with Tip60, Plk1, and cyclin B1 to inhibit Plk1-mediated phosphorylation of cyclin B1 at Ser133 position |
PubMed
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tat
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HIV-1 Tat induces a constitutive overexpression of cyclin B1 protein in human rhabdomyosarcoma cells |
PubMed
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Vif
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vif
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HIV-1 Vif-mediated G2 arrest involves the dysregulation of CDK1-CyclinB1 nuclear translocation |
PubMed
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Vpr
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vpr
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HIV-1 Vpr upregulates CCNB1 in HeLa cells within 12 hours of exposure |
PubMed
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vpr
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HIV-1 Vpr induces accumulation of the G2 cell cycle protein cyclin B1 and activation of caspase-3 and caspase-9 in multidrug-resistant human colorectal cancer cells |
PubMed
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vpr
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HIV-1 Vpr causes increased levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin beta |
PubMed
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vpr
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Vpr-induced cell cycle G2/M arrest reveals a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 theta |
PubMed
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vpr
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Rupture of HIV-1 Vpr-induced nuclear envelope herniations produces transient loss of the subcellular compartmentalization of Wee1, Cdc25C, cyclin B1, and presumably other soluble cellular components, resulting in their release into the cytoplasm |
PubMed
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vpr
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The human Vpr interacting protein (hVIP/MOV34) is a likely cellular cofactor for HIV-1 Vpr inactivation of the cdc2-cyclin B kinase complex and induction of cell cycle arrest |
PubMed
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vpr
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Data suggests that HIV-1 Vpr transactivation of the HIV-LTR promoter occurs through the inhibition of p300-associated cdc2-cyclin B kinase complex activity which enhances transcriptional activation by Rel A and p300 |
PubMed
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vpr
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Inactivation of the cdc2-cyclin B kinase complex by HIV-1 Vpr leads to the activation of Poly(A) polymerase |
PubMed
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vpr
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Inactivation of the cdc2-cyclin B kinase complex and arrest in the G2 phase of the cell cycle has been mapped to the C-terminus of HIV-1 Vpr, including amino acids 73, 80 and 84-96 |
PubMed
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vpr
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HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inactivating cdc25C, the phosphatase that dephosphorylates and activates cdc2 |
PubMed
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vpr
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HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inhibiting the dephosphorylation of cdc2 tyrosine 15, leading to arrest in the G2 phase of the cell cycle |
PubMed
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