LACRT lacritin [Homo sapiens (human)] - Gene

Summary

Official Symbol: LACRTprovided by HGNC
Official Full Name: lacritinprovided by HGNC
Primary source: HGNC:HGNC:16430
See related: Ensembl:ENSG00000135413 MIM:607360; AllianceGenome:HGNC:16430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward salivary gland (RPKM 2.0) See more
Orthologs: all
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Genomic context

Location:: 12q13.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (54630811..54634895, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (54597424..54601507, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (55024595..55028679, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis.
Title: Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis.
The Lacritin-Syndecan-1-Heparanase Axis in Dry Eye Disease
Title: The Lacritin-Syndecan-1-Heparanase Axis in Dry Eye Disease.
Data show increased levels of lysozyme C (LYZ), lacritin (LACRT) and zinc-alpha-2 glycoprotein 1 (AZGP1) in pooled tear fluid sample from Graves' disease (GD) patients with moderate-to-severe Graves' orbitopathy (GO) compared with GD patients without clinical signs of GO.
Title: Establishment of a tear protein biomarker panel differentiating between Graves' disease with or without orbitopathy.
cytoprotective effect of lacritin is mediated through Cyclooxygenase-2 (COX-2).
Title: Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death.
the C terminus of lacritin is multifunctional by dose and proteolytic processing and appears to play a key role in the innate protection of the eye
Title: A cleavage-potentiated fragment of tear lacritin is bactericidal.
Study involving 129 dry eye disease patients and 73 healthy controls, revealing significantly less tear lacritin in 95% of patients. Lacritin was one of seven proteins downregulated
Title: Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
iTRAQ analysis suggests that lacritin is selectively deficient in tears of patients with aqueous deficient dry eye.
Title: iTRAQ quantitative proteomics in the analysis of tears in dry eye patients.
Horse lacritin is 45% identical to human, and shares a predicted amphipathic alpha helix important for cell targeting.
Title: Detection of prosecretory mitogen lacritin in nonprimate tears primarily as a C-terminal-like fragment.
A direct ELISA was established to estimate lacritin levels in tears. An ELISA estimate of 4.2 ng lacritin per 100 ng total tear protein did not vary significantly among individuals of different ages (18 - 52 years), or gender.
Title: Tear lacritin levels by age, sex, and time of day in healthy adults.
Lacritin mRNA is the 24st most abundant in the lacrimal gland of Wolfring. Lacritin protein is detected by immunofluorescence.
Title: Gene expression in human accessory lacrimal glands of Wolfring.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables laminin-1 binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcineurin-NFAT signaling cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial structure maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcineurin-NFAT signaling cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation involved in wound healing	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macroautophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
involved_in tear secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in tear secretion	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: extracellular glycoprotein lacritin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.