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ZNF799 zinc finger protein 799 [ Homo sapiens (human) ]

Gene ID: 90576, updated on 27-Nov-2024

Summary

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Official Symbol
ZNF799provided by HGNC
Official Full Name
zinc finger protein 799provided by HGNC
Primary source
HGNC:HGNC:28071
See related
Ensembl:ENSG00000196466 MIM:619916; AllianceGenome:HGNC:28071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIT40; HIT-40; ZNF842
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta (RPKM 2.5), endometrium (RPKM 2.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF799 in Genome Data Viewer
Location:
19p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12390016..12415084, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12518440..12543482, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12500830..12512085, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12444503-12445368 Neighboring gene zinc finger protein 442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14052 Neighboring gene ribosomal protein S29 pseudogene 23 Neighboring gene NANOG hESC enhancer GRCh37_chr19:12501177-12501678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14055 Neighboring gene zinc finger protein 443 Neighboring gene zinc finger protein 709

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC71805

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 799
Names
zinc finger protein 14
zinc finger protein 842
zinc finger protein HIT-40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080821.3 → NP_001074290.1  zinc finger protein 799 isoform 1

    See identical proteins and their annotated locations for NP_001074290.1

    Status: VALIDATED

    Source sequence(s)
    AC008758
    Consensus CDS
    CCDS45989.1
    UniProtKB/Swiss-Prot
    Q96GE5
    Related
    ENSP00000411084.2, ENST00000430385.3
    Conserved Domains (5) summary
    smart00349
    Location:4 → 44
    KRAB; krueppel associated box
    COG5048
    Location:223 → 640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:478 → 498
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:518 → 542
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001322497.2 → NP_001309426.1  zinc finger protein 799 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA995448, AK027660, AL556986, HY132063
    Consensus CDS
    CCDS82297.1
    UniProtKB/TrEMBL
    D3YTF2
    Related
    ENSP00000415278.1, ENST00000419318.5
    Conserved Domains (3) summary
    COG5048
    Location:116 → 519
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:446 → 466
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:486 → 510
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001322498.2 → NP_001309427.1  zinc finger protein 799 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA995448, AC008758, AK027660, DA768219, DA910536
    Consensus CDS
    CCDS82297.1
    UniProtKB/TrEMBL
    D3YTF2
    Conserved Domains (3) summary
    COG5048
    Location:116 → 519
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:446 → 466
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:486 → 510
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12390016..12415084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439649.1 → XP_047295605.1  zinc finger protein 799 isoform X1

    UniProtKB/Swiss-Prot
    Q96GE5

  2. XM_047439650.1 → XP_047295606.1  zinc finger protein 799 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12518440..12543482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322555.1 → XP_054178530.1  zinc finger protein 799 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_203381.1: Suppressed sequence

    Description
    NM_203381.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96GE5.4 GenPept UniProtKB/Swiss-Prot:Q96GE5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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