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GP second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein [ Zaire ebolavirus ]

Gene ID: 911829, updated on 6-Oct-2023

Summary

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Gene symbol
GP
Gene description
second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein
Locus tag
ZEBOVgp4
Gene type
protein coding
RNA name
sGP
RefSeq status
PROVISIONAL
Organism
Zaire ebolavirus (isolate: Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae; Ebolavirus
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Genomic context

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Sequence:
NC_002549.1 (5900..8305)

NC_002549.1Genomic Context describing neighboring genes Neighboring gene nucleoprotein Neighboring gene polymerase complex protein Neighboring gene matrix protein Neighboring gene minor nucleoprotein Neighboring gene membrane-associated protein Neighboring gene RNA-dependent RNA polymerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002549.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity. Volchkov VE, et al. Science, 2001 Mar 9. PMID 11239157
  2. Ebola virus-like particle-induced activation of NF-kappaB and Erk signaling in human dendritic cells requires the glycoprotein mucin domain. Martinez O, et al. Virology, 2007 Aug 1. PMID 17434557, Free PMC Article
  3. Differential expression of the Ebola virus GP(1,2) protein and its fragments in E. coli. Das D, et al. Protein Expr Purif, 2007 Jul. PMID 17383893
  4. The nonstructural small glycoprotein sGP of Ebola virus is secreted as an antiparallel-orientated homodimer. Volchkova VA, et al. Virology, 1998 Oct 25. PMID 9792851
  5. [Molecular mechanisms of Ebola virus reproduction]. Subbotina EL, et al. Vopr Virusol, 2007 Jan-Feb. PMID 17338228

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Glycoprotein Mutation That Emerged during the 2013-2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion.
    Title: A Glycoprotein Mutation That Emerged during the 2013-2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion.
  2. A Virion-Based Assay for Glycoprotein Thermostability Reveals Key Determinants of Filovirus Entry and Its Inhibition.
    Title: A Virion-Based Assay for Glycoprotein Thermostability Reveals Key Determinants of Filovirus Entry and Its Inhibition.
  3. The EBOV glycoprotein (GP1,2) is the sole viral envelope protein and a major component of immunogenicity; it is encoded by the GP gene along with two truncated versions: soluble GP (sGP) and small soluble GP (ssGP). sGP may subvert the host immune response by inducing antibodies against sGP rather than GP1,2.
    Title: The Roles of Ebola Virus Soluble Glycoprotein in Replication, Pathogenesis, and Countermeasure Development.
  4. Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway.
    Title: Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway.
  5. the structure of the membrane proximal external region (MPER) connected to the TM domain: i.e., the missing parts of the EBOV GP2 structure. The structure, solved by solution NMR and EPR spectroscopy in membrane-mimetic environments, consists of a helix-turn-helix architecture that is independent of pH.
    Title: Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity.
  6. Ebola virus GP directly subverts the host's immune response by increasing the susceptibility of monocytes to Ebola virus infection.
    Title: Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection.
  7. report provides experimental evidence that the spontaneous mutation T544I is a tissue culture adaptation in certain cell lines and that it may be unique for the species Zaire ebolavirus; the mutation led to a marked increase in virus growth kinetics and conferred a robust growth advantage over wild-type rVSV-MAK-GP on Vero E6 cells
    Title: Spontaneous Mutation at Amino Acid 544 of the Ebola Virus Glycoprotein Potentiates Virus Entry and Selection in Tissue Culture.
  8. although Asn(563) and Asn(618) are not required for EBOV GP expression, they synergistically regulate its maturation, which determines its functionality.
    Title: Mechanistic understanding of N-glycosylation in Ebola virus glycoprotein maturation and function.
  9. Study determined the crystal structure of the primed GP (GPcl) of Ebola virus bound to domain C of NPC1 (NPC1-C); NPC1-C utilizes two protruding loops to engage a hydrophobic cavity on head of GPcl. Upon enzymatic cleavage and NPC1-C binding, conformational change in the GPcl further affects the state of the internal fusion loop, triggering membrane fusion.
    Title: Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1.
  10. Study presents the 3.6 A crystal structure of Marburg virus (strain Ravn) GP in complex with a cross-reactive antibody, MR78, from a human survivor, and a lower resolution structure of the antibody bound to Ebola virus(strain Zaire) GP.
    Title: Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Submit: New GeneRIF Correction See all GeneRIFs (30)

General gene information

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Homology

regulatory

  • Loc: 5900-5911 regulatory_class = other
  • Loc: 6918-6924 function = RNA editing , regulatory_class = other
  • Loc: 8288-8299 regulatory_class = other
  • Loc: 8295-8305 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein
NP_066246.1
  • virion spike glycoprotein precursor; an additional A residue is inserted during transcription; encodes two disulfide linked subunits GP1 and GP2
NP_066247.1
  • sGP, small non-structural, secreted glycoprotein; sGP secreted as an anti-parallel oriented homodimer
NP_066248.1
  • second non-structural secreted glycoprotein; super small secreted glycoprotein; secreted in a monomeric form; one A residue is deleted or two additional A residues are inserted at the editing site during transcription of the GP gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002549.1 Reference assembly

    Range
    5900..8305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_066246.1 spike glycoprotein [Zaire ebolavirus]

    See identical proteins and their annotated locations for NP_066246.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q05320, Q66818, Q77LU5, Q8B9S1, Q8JS62
    UniProtKB/TrEMBL
    A0A089X075, A0A0E3NBB1, A9QPL9, L7QHR7
    Conserved Domains (3) summary
    cd09850
    Location:557 → 629
    Ebola-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains
    pfam01611
    Location:15 → 348
    Filo_glycop; Filovirus glycoprotein
    cl28464
    Location:341 → 493
    Spr; Cell wall-associated hydrolase, NlpC family [Cell wall/membrane/envelope biogenesis]

  2. NP_066247.1 small secreted glycoprotein [Zaire ebolavirus]

    See identical proteins and their annotated locations for NP_066247.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O11458, O12421, O12717, P60170, P60171, P87670, Q66801, Q66819, Q6V1Q6, Q77LU4, Q8JS61, Q9YMG3
    UniProtKB/TrEMBL
    A0A089YMW7, A0A096YGX7, A0A0E3H7K0, A0A0G2YKH9, A0A2U9QPY9, A0A3G1S941, A9QPM0, I0DHB0, L7QI98
    Conserved Domains (1) summary
    pfam01611
    Location:15 → 298
    Filo_glycop; Filovirus glycoprotein

  3. NP_066248.1 second secreted glycoprotein [Zaire ebolavirus]

    See identical proteins and their annotated locations for NP_066248.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A096YGX1, A0A0G2YD57, A0A2U9QPX5, A0A3G1TWX0, A0A3G2LME3, G8DB42, L7QHT8, L7QHW1, Q6V1Q5
    Conserved Domains (1) summary
    pfam01611
    Location:15 → 295
    Filo_glycop; Filovirus glycoprotein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAD14584.1
AAD14585.1
AAD14586.1

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