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tir T3SS translocated intimin receptor Tir [ Escherichia coli O157:H7 str. Sakai ]

Gene ID: 915465, updated on 6-Oct-2023

Summary

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Gene symbol
tir
Gene description
T3SS translocated intimin receptor Tir
Locus tag
ECs_4561
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli O157:H7 str. Sakai (strain: Sakai, substrain: RIMD 0509952, serovar: O157:H7)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
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Genomic context

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Sequence:
NC_002695.2 (4600055..4601731, complement)

NC_002695.2Genomic Context describing neighboring genes Neighboring gene T3SS intimin Neighboring gene T3SS chaperone CesT Neighboring gene T3SS secreted effector Map Neighboring gene T3SS chaperone CesF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002695.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The established intimin receptor Tir and the putative eucaryotic intimin receptors nucleolin and beta1 integrin localize at or near the site of enterohemorrhagic Escherichia coli O157:H7 adherence to enterocytes in vivo. Sinclair JF, et al. Infect Immun, 2006 Feb. PMID 16428775, Free PMC Article
  2. A carboxy-terminal domain of Tir from enterohemorrhagic Escherichia coli O157:H7 (EHEC O157:H7) required for efficient type III secretion. Allen-Vercoe E, et al. FEMS Microbiol Lett, 2005 Feb 15. PMID 15686835
  3. Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor. Sinclair JF, et al. J Biol Chem, 2004 Aug 6. PMID 15173179
  4. Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA. McNeilly TN, et al. PLoS One, 2015. PMID 26020530, Free PMC Article
  5. Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP. Cantarelli VV, et al. Cell Microbiol, 2007 Jul. PMID 17451412

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA
    Title: Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA.
  2. identified a 6 amino acid (519-524) carboxy-terminal region which was required for efficient Tir secretion and translocation; data suggest that this region may play a role in maintaining EHEC O157:H7 Tir in a secretion-competent conformation
    Title: A carboxy-terminal domain of Tir from enterohemorrhagic Escherichia coli O157:H7 (EHEC O157:H7) required for efficient type III secretion.
  3. localizes at or near the site of enterohemorrhagic Escherichia coli O157:H7 adherence to enterocytes in piglets, neonatal calves, and mice.
    Title: The established intimin receptor Tir and the putative eucaryotic intimin receptors nucleolin and beta1 integrin localize at or near the site of enterohemorrhagic Escherichia coli O157:H7 adherence to enterocytes in vivo.
  4. Binding of cortactin to Tir and EspF(u), is dependent upon tyrosine phosphorylation and a balance between tyrosine phosphorylation and dephosphorylation of cortactin is required to regulate pedestal formation by EHEC.
    Title: Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
T3SS translocated intimin receptor Tir

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002695.2 Reference assembly

    Range
    4600055..4601731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_312588.1 T3SS translocated intimin receptor Tir [Escherichia coli O157:H7 str. Sakai]

    See identical proteins and their annotated locations for NP_312588.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    E2IPB9
    Conserved Domains (3) summary
    pfam07490
    Location:1 → 267
    Tir_receptor_N; Translocated intimin receptor (Tir) N-terminus
    pfam03549
    Location:269 → 333
    Tir_receptor_M; Translocated intimin receptor (Tir) intimin-binding domain
    pfam07489
    Location:334 → 558
    Tir_receptor_C; Translocated intimin receptor (Tir) C-terminus
Nucleotide Protein
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