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eae T3SS intimin [ Escherichia coli O157:H7 str. Sakai ]

Gene ID: 915471, updated on 1-Apr-2024

Summary

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Gene symbol
eae
Gene description
T3SS intimin
Locus tag
ECs_4559
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli O157:H7 str. Sakai (strain: Sakai, substrain: RIMD 0509952, serovar: O157:H7)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
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Genomic context

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Sequence:
NC_002695.2 (4596583..4599387, complement)

NC_002695.2Genomic Context describing neighboring genes Neighboring gene T3SS secretion switching protein SepL Neighboring gene T3SS structure protein EscD Neighboring gene T3SS chaperone CesT Neighboring gene T3SS translocated intimin receptor Tir

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002695.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic Characterization of Intimin Gene (eae) in Clinical Shiga Toxin-Producing Escherichia coli Strains from Pediatric Patients in Finland. Wang L, et al. Toxins (Basel), 2023 Nov 23. PMID 38133173, Free PMC Article
  2. Interaction of enteropathogenic and Shiga toxin-producing Escherichia coli and porcine intestinal mucosa: role of intimin and Tir in adherence. Girard F, et al. Infect Immun, 2005 Sep. PMID 16113321, Free PMC Article
  3. Shiga Toxin-Producing Escherichia coli Infection in Jönköping County, Sweden: Occurrence and Molecular Characteristics in Correlation With Clinical Symptoms and Duration of stx Shedding. Bai X, et al. Front Cell Infect Microbiol, 2018. PMID 29765909, Free PMC Article
  4. Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor. Sinclair JF, et al. J Biol Chem, 2004 Aug 6. PMID 15173179
  5. Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA. McNeilly TN, et al. PLoS One, 2015. PMID 26020530, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic Characterization of Intimin Gene (eae) in Clinical Shiga Toxin-Producing Escherichia coli Strains from Pediatric Patients in Finland.
    Title: Genetic Characterization of Intimin Gene (eae) in Clinical Shiga Toxin-Producing Escherichia coli Strains from Pediatric Patients in Finland.
  2. The presence of stx2 in stool could be used as risk predictor at an early stage. Shiga toxin-producing Escherichia coli isolates with stx2 toxin and intimin protein were significantly associated with bloody diarrhea.
    Title: Shiga Toxin-Producing Escherichia coli Infection in Jönköping County, Sweden: Occurrence and Molecular Characteristics in Correlation With Clinical Symptoms and Duration of stx Shedding.
  3. intimins and invasins represent a very small minority of the sequence diversity in what has been previously the "intimin/invasin protein family
    Title: Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family.
  4. Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA
    Title: Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA.
  5. influences intestinal adherence and tropism of attaching and effecing E. coli (AEEC) strains
    Title: Interaction of enteropathogenic and Shiga toxin-producing Escherichia coli and porcine intestinal mucosa: role of intimin and Tir in adherence.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
T3SS intimin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002695.2 Reference assembly

    Range
    4596583..4599387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_312586.1 T3SS intimin [Escherichia coli O157:H7 str. Sakai]

    See identical proteins and their annotated locations for NP_312586.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    B5ARQ5
    Conserved Domains (5) summary
    smart00634
    Location:659 → 743
    BID_1; Bacterial Ig-like domain (group 1)
    smart00635
    Location:758 → 836
    BID_2; Bacterial Ig-like domain 2
    pfam07979
    Location:839 → 934
    Intimin_C; Intimin C-type lectin domain
    pfam01476
    Location:65 → 113
    LysM; LysM domain
    pfam11924
    Location:169 → 442
    IAT_beta; Inverse autotransporter, beta-domain
Nucleotide Protein
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