U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF764 zinc finger protein 764 [ Homo sapiens (human) ]

Gene ID: 92595, updated on 10-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF764provided by HGNC
Official Full Name
zinc finger protein 764provided by HGNC
Primary source
HGNC:HGNC:28200
See related
Ensembl:ENSG00000169951 MIM:619524; AllianceGenome:HGNC:28200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables transcription coregulator activity. Involved in cellular response to glucocorticoid stimulus. Is active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in spleen (RPKM 2.6), stomach (RPKM 2.6) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF764 in Genome Data Viewer
Location:
16p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30553764..30558374, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30940731..30945341, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30565085..30569695, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ZNF747 divergent transcript Neighboring gene RPL7L1 pseudogene 16 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30552221-30552866 Neighboring gene uncharacterized LOC124903677 Neighboring gene Sharpr-MPRA regulatory region 8694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30564727-30565226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30568583-30569144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30580811-30581376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30581377-30581940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7379 Neighboring gene zinc finger protein 688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30596216-30596816 Neighboring gene zinc finger protein 785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30597418-30598018 Neighboring gene zinc finger protein 689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7381 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30621737-30622706 Neighboring gene uncharacterized LOC124903678

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ZNF764 haploinsufficiency may explain partial glucocorticoid, androgen, and thyroid hormone resistance associated with 16p11.2 microdeletion. Kino T, et al. J Clin Endocrinol Metab, 2012 Aug. PMID 22577170, Free PMC Article
  2. Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor. Fadda A, et al. Sci Rep, 2017 Jan 31. PMID 28139699, Free PMC Article
  3. The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. Helleboid PY, et al. EMBO J, 2019 Sep 16. PMID 31403225, Free PMC Article
  4. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  5. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. effect of ZNF764 on the glucocorticoid receptor transcriptional activity was mediated through cooperation with a general nuclear hormone receptor coactivator, transcriptional intermediary factor 1
    Title: ZNF764 haploinsufficiency may explain partial glucocorticoid, androgen, and thyroid hormone resistance associated with 16p11.2 microdeletion.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC13138

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to glucocorticoid stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 764

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172679.2 → NP_001166150.1  zinc finger protein 764 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks one internal amino acid, compared to isoform 1.
    Source sequence(s)
    AC002310, AK093992, BC008821, BF725095
    Consensus CDS
    CCDS54001.1
    UniProtKB/Swiss-Prot
    Q96H86
    Related
    ENSP00000378526.2, ENST00000395091.3
    Conserved Domains (5) summary
    smart00349
    Location:26 → 85
    KRAB; krueppel associated box
    COG5048
    Location:228 → 293
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:232 → 252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:26 → 65
    KRAB; KRAB box
    pfam13465
    Location:300 → 325
    zf-H2C2_2; Zinc-finger double domain

  2. NM_033410.4 → NP_219363.2  zinc finger protein 764 isoform 1

    See identical proteins and their annotated locations for NP_219363.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC002310, AK093992, BC008821, BF725095
    Consensus CDS
    CCDS10683.1
    UniProtKB/Swiss-Prot
    A8MZF4, B3KSN2, H9KV99, Q96H86, Q9BWS1
    Related
    ENSP00000252797.2, ENST00000252797.6
    Conserved Domains (5) summary
    smart00349
    Location:26 → 85
    KRAB; krueppel associated box
    COG5048
    Location:229 → 294
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:233 → 253
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:26 → 65
    KRAB; KRAB box
    pfam13465
    Location:301 → 326
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    30553764..30558374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    30940731..30945341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96H86.2 GenPept UniProtKB/Swiss-Prot:Q96H86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous