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TP53INP1 tumor protein p53 inducible nuclear protein 1 [ Homo sapiens (human) ]

Gene ID: 94241, updated on 27-Nov-2024

Summary

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Official Symbol
TP53INP1provided by HGNC
Official Full Name
tumor protein p53 inducible nuclear protein 1provided by HGNC
Primary source
HGNC:HGNC:18022
See related
Ensembl:ENSG00000164938 MIM:606185; AllianceGenome:HGNC:18022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B
Summary
Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of DNA-templated transcription; and positive regulation of autophagy. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver (RPKM 25.0), testis (RPKM 21.8) and 25 other tissues See more
Orthologs
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Genomic context

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See TP53INP1 in Genome Data Viewer
Location:
8q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94925972..94949378, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (96050944..96074374, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95938200..95961606, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:95906241-95906802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19374 Neighboring gene cyclin E2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27636 Neighboring gene small nucleolar RNA U13 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:95960947-95961575 and GRCh37_chr8:95961576-95962205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27639 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:95974156-95974312 Neighboring gene NANOG hESC enhancer GRCh37_chr8:95987500-95988063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:96036276-96037122 Neighboring gene Sharpr-MPRA regulatory region 2014 Neighboring gene RNA, U6 small nuclear 1209, pseudogene Neighboring gene uncharacterized LOC124901981

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization. Nowak J, et al. Cytogenet Genome Res, 2002. PMID 12438758
  2. Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer. Jiang PH, et al. World J Gastroenterol, 2006 Feb 7. PMID 16521180, Free PMC Article
  3. High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid. Ito Y, et al. Pathology, 2006 Dec. PMID 17393983
  4. TP53inp1 Gene Is Implicated in Early Radiation Response in Human Fibroblast Cells. Sándor N, et al. Int J Mol Sci, 2015 Oct 23. PMID 26512655, Free PMC Article
  5. TP53INP1 overexpression in prostate cancer correlates with poor prognostic factors and is predictive of biological cancer relapse. Giusiano S, et al. Prostate, 2012 Feb 1. PMID 21538421

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An approach for an enhanced anticancer activity of ferulic acid-loaded polymeric micelles via MicroRNA-221 mediated activation of TP53INP1 in caco-2 cell line.
    Title: An approach for an enhanced anticancer activity of ferulic acid-loaded polymeric micelles via MicroRNA-221 mediated activation of TP53INP1 in caco-2 cell line.
  2. miR-8485 alleviates the injury of cardiomyocytes through TP53INP1.
    Title: miR-8485 alleviates the injury of cardiomyocytes through TP53INP1.
  3. LncRNA n339260 functions in hepatocellular carcinoma progression via regulation of miRNA30e-5p/TP53INP1 expression.
    Title: LncRNA n339260 functions in hepatocellular carcinoma progression via regulation of miRNA30e-5p/TP53INP1 expression.
  4. MiR-155 inhibits TP53INP1 expression leading to enhanced glycolysis of psoriatic mesenchymal stem cells.
    Title: MiR-155 inhibits TP53INP1 expression leading to enhanced glycolysis of psoriatic mesenchymal stem cells.
  5. MicroRNA-106a regulates autophagy-related cell death and EMT by targeting TP53INP1 in lung cancer with bone metastasis.
    Title: MicroRNA-106a regulates autophagy-related cell death and EMT by targeting TP53INP1 in lung cancer with bone metastasis.
  6. circCDYL Acts as a Tumor Suppressor in Triple Negative Breast Cancer by Sponging miR-190a-3p and Upregulating TP53INP1.
    Title: circCDYL Acts as a Tumor Suppressor in Triple Negative Breast Cancer by Sponging miR-190a-3p and Upregulating TP53INP1.
  7. TP53INP1 exerts neuroprotection under ageing and Parkinson's disease-related stress condition.
    Title: TP53INP1 exerts neuroprotection under ageing and Parkinson's disease-related stress condition.
  8. FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway.
    Title: FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway.
  9. Exosomal miR-155-5p promotes proliferation and migration of gastric cancer cells by inhibiting TP53INP1 expression.
    Title: Exosomal miR-155-5p promotes proliferation and migration of gastric cancer cells by inhibiting TP53INP1 expression.
  10. Long non-coding RNA MIR155HG knockdown suppresses cell proliferation, migration and invasion in NSCLC by upregulating TP53INP1 directly targeted by miR-155-3p and miR-155-5p.
    Title: Long non-coding RNA MIR155HG knockdown suppresses cell proliferation, migration and invasion in NSCLC by upregulating TP53INP1 directly targeted by miR-155-3p and miR-155-5p.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22139, DKFZp434M1317

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antioxidant activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagic cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to UV IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hydroperoxide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to methyl methanesulfonate IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of myofibroblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tumor protein p53-inducible nuclear protein 1
Names
p53-dependent damage-inducible nuclear protein 1
p53-inducible p53DINP1
stress-induced protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135733.2 → NP_001129205.1  tumor protein p53-inducible nuclear protein 1 isoform b

    See identical proteins and their annotated locations for NP_001129205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1 that has an in-frame stop codon in it. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB017926, AF409114, DB086880
    Consensus CDS
    CCDS47899.1
    UniProtKB/Swiss-Prot
    Q96A56
    Related
    ENSP00000390063.2, ENST00000448464.6
    Conserved Domains (1) summary
    pfam14839
    Location:25 → 158
    DOR; DOR family

  2. NM_033285.4 → NP_150601.1  tumor protein p53-inducible nuclear protein 1 isoform a

    See identical proteins and their annotated locations for NP_150601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AB017926, AF409115, DB086880
    Consensus CDS
    CCDS6265.1
    UniProtKB/Swiss-Prot
    B2RCE5, Q969R9, Q96A56
    Related
    ENSP00000344215.4, ENST00000342697.5
    Conserved Domains (1) summary
    pfam14839
    Location:25 → 231
    DOR; DOR family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    94925972..94949378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517386.3 → XP_011515688.1  tumor protein p53-inducible nuclear protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011515688.1

    UniProtKB/Swiss-Prot
    B2RCE5, Q969R9, Q96A56
    Conserved Domains (1) summary
    pfam14839
    Location:25 → 231
    DOR; DOR family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    96050944..96074374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361537.1 → XP_054217512.1  tumor protein p53-inducible nuclear protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RCE5, Q969R9, Q96A56
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96A56.1 GenPept UniProtKB/Swiss-Prot:Q96A56

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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