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sspA stringent starvation protein A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944744, updated on 3-Dec-2024

Summary

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Official Symbol
sspA
Official Full Name
stringent starvation protein A
Primary source
ECOCYC:EG10977
Locus tag
b3229
See related
ASAP:ABE-0010594
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3218; pog; ssp
Summary
The SspA protein is associated with RNA polymerase and is required for transcriptional activation of the bacteriophage P1 late promoter in vivo and in vitro . [More information is available at EcoCyc: EG10977].
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Genomic context

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Sequence:
NC_000913.3 (3376782..3377420, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter DcuD Neighboring gene ClpXP protease specificity-enhancing factor Neighboring gene 30S ribosomal subunit protein S9 Neighboring gene 50S ribosomal subunit protein L13

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subunits of RNA polymerase in function and structure. IX. Regulation of RNA polymerase activity by stringent starvation protein (SSP). Ishihama A, et al. J Mol Biol, 1979 Apr 25. PMID 383996
  2. Biosynthetic regulation of individual proteins in relA+ and relA strains of Escherichia coli during amino acid starvation. Reeh S, et al. Mol Gen Genet, 1976 Dec 22. PMID 799246
  3. Genetic mapping of the Escherichia coli gene for the stringent starvation protein and its dispensability for normal cell growth. Fukuda R, et al. Mol Gen Genet, 1988 Mar. PMID 2835636
  4. Cloning of the Escherichia coli gene for the stringent starvation protein. Fukuda R, et al. Mol Gen Genet, 1985. PMID 3003520
  5. Structural basis for the function of stringent starvation protein a as a transcription factor. Hansen AM, et al. J Biol Chem, 2005 Apr 29. PMID 15735307

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Electrophysiological analysis revealed that SspA auto-inserts into lipid bilayers and forms IAA-94-sensitive ion channels. Substituting the ubiquitously conserved residue leucine 29 to alanine in the pore-forming region increased its single-channel conductance.
    Title: Identification and Characterization of a Bacterial Homolog of Chloride Intracellular Channel (CLIC) Protein.
  2. SspA positively regulates the expression of enterohemorrhagic Escherichia coli virulence factors by restricting the intracellular level of H-NS.
    Title: SspA up-regulates gene expression of the LEE pathogenicity island by decreasing H-NS levels in enterohemorrhagic Escherichia coli.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  4. SspA is a global regulator, which acts upstream of H-NS, and thereby plays an important role in the stress response of E. coli during stationary phase
    Title: SspA is required for acid resistance in stationary phase by downregulation of H-NS in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
stringent starvation protein A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3376782..3377420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417696.1 stringent starvation protein A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417696.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0FK24
    Conserved Domains (1) summary
    PRK09481
    Location:1 → 211
    sspA; stringent starvation protein A; Provisional
Nucleotide Protein
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